Čes. slov. farm. 2002, 51(2):99-101
Pre-Formulation Studies of a Potential Local Anaesthetic from the Group of Phenylcarbamic Acid Derivatives
- Lékarna Plus, Praha
Within pre-formulation studies of phenylcarbamic acid derivatives with local anaesthetic effects, potential drog IV with the chemical name N-(2-(2-ethylphenylcarbamoyloxy)-ethyl)-piperidiniumchloride was examined. The study evaluated the effect of polyhydric alcohols - glycerol, propylene glycol, sorbitol and their concentrations of 5; 10; 15, and 20 wt % on the values of the partition coefficient in the system n-octanoUwater, surface tension, and viskozity of the solutions of potential drog IV. The optimal auxiliary substance seems to be glycerol of a concentration of 15-20 wt %, as it does not affect the values of the partition coefficient and surface tension of potential drog IV solutions in a statistically significant manner.
Keywords: partition coefficient; surface tension; viskozity; N-(2-(2-ethylphenylcarbamoyloxy)-ethyl)-piperidiniumchloride
Published: February 1, 2002 Show citation