ACE INHIBÍTOR KAPTOPRIL VO SVETLE NOVŠÍCH KLINICKÝCH ŠTÚDIÍ

Čes. slov. farm. 2002, 51(2):63-67

The ACE Inhibitor Captopril in the Light of Recent Clinical Studies

F. Šimko, M. Šimková, L. Kovács: Ústav patologickej fyziológie a III. interná klinika Lekárskej fakulty Univerzity Komenského, Bratislava; II. detská klinika Lekárskej fakulty Univerzity Komenského a Detskej fakultnej NsP a Laboratórium molekulárnej genetiky Lekárskej fakulty Univerzity K

Captopril, the classic inhibitor of the angiotensin converting enzyme, was employed in several large clinical studies in retem years. The effect of captopril was compared either with placebo, or captopril was selected as the reference ACE inhibitor for comparison with another therapy. In the classic study SAVE, captopril administered to patients after myocardial infarction with a dysfunction of the left chamber reduced mortality by 19 %. Though in the study ELITE the ATl blocker losartan was more effective to reduce mortality in patients with chronic heart failure than captopril, the larger and mortality-oriented study ELITE II did not demonstrate a difference in mortality reduction between captopril and losartan. ACE inhibitors thus remain drugs of choice in chronic heart failure. ATl blockrs are to be used in the cases when ACE inhibitors are not tolerated. The study CAPPP has demonstrated tkat captopril in hypertonic patients not only effectively decreases blond pressure but exerts a similar effect on mortality reduction as the classic treatment with a diuretic and a betablocker, the most effective being captopril in diabetic patients. Administration of captopril in hypertonic patients with diabetes mellitus in the study UKPDS had an effect on mortality reduction as well as mitro- and macrovascular complications of diabetes similar to tkat of atenolol. The ongoing study VALIANT compares the ATl blocker valsartan or a combination of valsartan and captopril with captopril alone on patients at risk after myocardial infarction. Also at the beginning of the 21St century captopril maintains a stable position in the treatment of the cardiovascular system.