JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2002, 51(2):55-62

Inhibitors of 5-Lipoxygenase

M. Gápovský, M. Remko
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

Leukotrienes are powerfizl mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4, Transformation of arachidonic acid to LTA4 is catalyzed by the enzyme 5-lipoxygenase and faciliated by FLAP. The present paper discusses the results of recent development of new drugs in this area.

Keywords: leukotrienes; 5-lipoxygenase; inhibition of leukotriene synthesis; zileuton

Published: February 1, 2002  Show citation

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Gápovský M, Remko M. Inhibitors of 5-Lipoxygenase. Čes. slov. farm. 2002;51(2):55-62.
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