JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2001, 50(4):197-202

Analytical Evaluation of the Substance BL 443 Pivalate

®. Bezáková, M. Stankovičová, J. Csöllei
Ústav chemických liečiv Veterinárnej a farmaceutickej Univerzity, Brno
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

The paper presents the results of an analytical evaluation and a study of some physicochemicalproperties of a new potential drug of the prodrug type Πthe substance BL 443 pivalate with anassumed antidysrhythmic effect. The structure of the substance has been confirmed by elementalanalysis, IR and UV spectroscopy. The following parameters were determined: melting point,solubility, dissociation constant, experimental partition coefficient in four different systems, and surface activity. The chromatographic behaviour of the drug on a thin layer (adsorption andpartition chromatography) was also investigated. Acidimetric titration in non-aqueous medium andspectrophotometry in the ultraviolet region of the spectrum at the wavelength of the second absorption maximum of the drug was employed to determine the content of the drug in pure substance.

Keywords: prodrug; BL 443 pivalate: butylester of [(2-pivaloyloxy-3-isopropylamino)-propoxy]phenylcarbamic acid; analytical profile; physicochemical properties

Published: April 1, 2001  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bezáková ®, Stankovičová M, Csöllei J. Analytical Evaluation of the Substance BL 443 Pivalate. Čes. slov. farm. 2001;50(4):197-202.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)

    • Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.