Čes. slov. farm. 2001, 50(4):193-196

Effect of Losartan on the Antioxidant Status of Rats with Diabetes Mellitus

A. Liptáková¹, O. Uličná², Z. Ďurčková¹, P. Božek³, O. Vančová²

¹ Ústav lekárskej chémie, biochémie a klinickej biochémie LF UK, Bratislava

² Farmakobiochemické laboratórium III. internej kliniky LF UK, Bratislava

³ Nemocnica s poliklinikou Ministerstva vnútra, Bratislava

The aim of this study was to monitor the effect of the administration of antihypertensive druglosartan on: (1) the antioxidant status of rats with experimental insulin-dependent diabetesmellitus; (2) oxidative damage which is represented by the production of compounds which can reactwith thiobarbituric acid (TBARP), and (3) some metabolic parameters. Losartan administration didnot significantly influence the concentration of glucose, cholesterol, triacylglycerol, and uric acid inthe plasma of control and diabetic animals. In the liver tissue, the concentration of triacylglycerolsdecreased after losartan administration, but the concentration of cholesterol did not change. Thepresent authors have found that losartan administration increased the levels of water solubileantioxidants in the plasma of diabetic rats, which can result in a decrease of the TBARP levels inthe plasma of diabetic rats.

Keywords: antioxidant status; losartan; diabetes mellitus; oxidative stress

Published: April 1, 2001  Show citation