Čes. slov. farm. 2000, 49(4):199-200
Oxidative Determination of Hydroxyamphetamine in Drops by the Method of FlowInjection Analysis
- Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (Ce IV) as the oxidation reagent. Under optimised conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78 % for 0.05 mmol.l-1 (n=10) and a sample through put of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.
Keywords: hydroxyamphetamine; Ce IV; flow injection analysis; spectrophotometric determination; drops
Published: April 1, 2000 Show citation