JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2000, 49(4):185-189

Physicochemical in vitro and in vivo Investigation of the Depot Formation of Cinchocaine in Atelocollagen Felt

J. Ludvík, J. Prokeš, A. Galatík, J. Fanta
Ústav fyzikální chemie J. Heyrovského Akademie věd ČR, Praha
Ústav toxikologie, 1. lékařské fakulty Univerzity Karlovy, Praha
HYPRO, Otrokovice
Chirurgická klinika Fakultní nemocnice Královské Vinohrady, Praha

The paper presents an introductory physicochemical study dealing with the preparation of atelocol-lagen felt saturated with local anesthetics, with the modelling of the release of the anesthetic fromthe collagen matrix in vitro, and with the checking of the corresponding analytical procedures(dc-polarography and UV-VIS spectrophotometry) for the determination of cinchocaine. The studyis supplemented with experiments in vivo that confirm the usability of the new material for thedepot formation of local anesthetics.

Keywords: atelocollagen; local anesthetics; cinchocaine; depot formation; dc-polarography; UV-VIS spectrophotometry; LD50

Published: April 1, 2000  Show citation

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Ludvík J, Prokeš J, Galatík A, Fanta J. Physicochemical in vitro and in vivo Investigation of the Depot Formation of Cinchocaine in Atelocollagen Felt. Čes. slov. farm. 2000;49(4):185-189.
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