JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2000, 49(2):88-90

Determination of Xanthinol Nicotinate in Dosage Forms by Capillary Isotachophoresis

M. Pospíšilová, V. Jokl, J. Dolejšová
Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové

Cationic capillary isotachophoresis (ITP) with coductimetric detection has been used for separating and determination of xanthinol in two commercial mass-produced preparations. The optimized ITP electrolyte system consisted of 5 mM potassium picolinate + 5 mM picolinic acid (pH 5.21) as the leading electrolyte and 10 mM formic acid as the terminating electrolyte. The driving and detection currents were 50 mA (for 380 s) and 10 mA, respectively. The analysis took about 8 min. According to the validation procedure based on the reference UV spectrophotometric method, the ITP method gave practically the same results.

Keywords: xanthinol; isotachophoresis; pharmaceutical analysis

Published: February 1, 2000  Show citation

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Pospíšilová M, Jokl V, Dolejšová J. Determination of Xanthinol Nicotinate in Dosage Forms by Capillary Isotachophoresis. Čes. slov. farm. 2000;49(2):88-90.
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