Čes. slov. farm. 1999, 48(6):272-275
In vitro Effect of Quinolones on Hydrophobicity of Acinetobacter baumannii
- Ústav preventívnej a klinickej medicíny, Bratislava
Effects of subinhibitory concentrations (sub-MICs) (1/4, 1/8, 1/16 or 1/32 of the MICs) of fourquinolone antibiotics on surface hydrophobicity of two Acinetobacter baumannii strains (R1 and R2) were tested. Hydrophobicity was evaluated by adherence of bacteria to xylene and their aggregationin ammonium sulphate solutions. Norfloxacin in concentrations of 1/4 or 1/8 of the MIC decreasedhydrophobicity of R1 strain and of R2 strain in concentration of 1/16 of the MIC. Ciprofloxacin was efficient for both strains mainly in concentration of 1/4 of their MICs. Enoxacin (1/8 MIC) more effectively reduced hydrophobic properties only in R2 strain. The other concentrations of the above-mentioned antibiotics as well as all tested concentrations of pefloxacin practically did not affect bacterial surface hydrophobicity.
Keywords: quinolones; subinhibitory concentrations; Acinetobacter baumannii; surface hydrophobicity
Published: June 1, 1999 Show citation