JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 1999, 48(4):183-185

Comparative Study of the Application of Sulfo and Carboxy Azo Dyes as Reagents in theIon-pair Extraction Spectrophotometric Determination of Basic Drugs

J. Gasparič, V. Hojný, V. Kubíček
Katedra biofyziky a fyzikální chemie farmaceutické fakulty Univerzity Karlovy, Hradec Králové

The application of acid hydroxy or amino azo dyes containng sulfo or carboxy groups as reagents forthe determination of tetra-n-butylammonium bromide as the model compound was compared. Thesulfonated dyes are applicable within a broad range of pH 2-10 with the exception of amino azodyes, the protonated form of which, formed at pH < 3, is precipitated from the solution. Theapplication of carboxy azo dyes, owing to their high pKA values, is strongly limited to very high pHvalues. Methyl red is an exception, its pKA value is in the range of 4.88-5.06.

Keywords: extraction spectrophotometry; methyl red; sulfo azo dyes; carboxy azo dyes; tetra-n-butylammonium bromide

Published: April 1, 1999  Show citation

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Gasparič J, Hojný V, Kubíček V. Comparative Study of the Application of Sulfo and Carboxy Azo Dyes as Reagents in theIon-pair Extraction Spectrophotometric Determination of Basic Drugs. Čes. slov. farm. 1999;48(4):183-185.
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