JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 1999, 48(2):72-74

Density of Lyophilised Ophthalmic Lamellae2. Use of the Correlogram of Xerogel Density

Z. Zatloukal
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové

The paper examines the vacillation of the density of the foil lyophilised from hydrogel containing40 g/l of hydroxypropylmethylcellulose (HPMC 4000). Lamellae of a diameter of 0.55 cm were formedto estimate the density of cm 2 of xerogel. In comparison with traditional regressive methods, theuse of a two-dimensional correlogram is recommended. The most important finding is the achieve-ment of random vacillation of density in a distance of ca 2 cm in connection with stamping lamellaefrom the lyophilised foil. The findings make it possible to optimise the procedure of pouring hydrogelfor lyophilisation with a subsequent decrease in density vacillation of lyophilised ophthalmic lamellae.

Keywords: lyophilisation; hydroxypropylmethylcellulose; xerogel; density; correlogram

Published: February 1, 1999  Show citation

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Zatloukal Z. Density of Lyophilised Ophthalmic Lamellae2. Use of the Correlogram of Xerogel Density. Čes. slov. farm. 1999;48(2):72-74.
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