JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 1999, 48(1):21-26

A Study of Labeling Conditions of Derivatives of (2RS, 4R)-1,3-Carboxylic Acid with Technetium-99m

A. Bumbálová, E. Havránek, J. Ja'afreh, V. Kettmann, J. Světlík, O. Štroffeková
Katedra farmaceutickej analýzy a nukleárnej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava

The preparation of 99mTc-complexes with twenty derivatives of (2RS,4R)-1,3-thiazolidin-4-carboxylic acid over a broad pH range (1.5-8.9) is described for a potential use in radiodiagnostic medicine. The labelling efficiency was checked by paper and thin layer chromatography and for all well-soluble compounds is higher than 90 %. Paper electrophoresis and gel chromatography indicated the presence of two types of complexes differing in charge and molecular mass. The structure of both types of the 99mTc-complexes is also discussed. The organ distribution and its time dependence were determined in mice after i.v. application.

Keywords: radiodiagnostics; 99mTc-complexes; derivatives ofthiazolidin-4-carboxylic acid

Published: January 1, 1999  Show citation

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Bumbálová A, Havránek E, Ja'afreh J, Kettmann V, Světlík J, Štroffeková O. A Study of Labeling Conditions of Derivatives of (2RS, 4R)-1,3-Carboxylic Acid with Technetium-99m. Čes. slov. farm. 1999;48(1):21-26.
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