JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 1998, 47(6):276-278

Density of Lyophilised Ophthalmic Lamellae

Z. Zatloukal
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové

The present paper examines the effect of the concentration of hydroxypropylmethylcellulose (HPMC 4000) 20-60 g/l in hydrogel on the density of lyophilised xerogel. Lamellae of a diameter of 5.5 mm were obtained by stamping from lyophilised foils and their density was estimated. With decreasing HPMC 4000 concentration in hydrogel, the density of lamellae decreases to values within 50-55 g/l. The causes of this phenomenon and its consequences for optimisation of technology of lyophilised ophthalmic lamellae are discussed.

Keywords: hydroxypropylmethylcellulose; hydrogel; lyophilisation; xerogel density

Published: June 1, 1998  Show citation

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Zatloukal Z. Density of Lyophilised Ophthalmic Lamellae. Čes. slov. farm. 1998;47(6):276-278.
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