JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2016, 65(6):221-225 | DOI: 10.36290/csf.2016.043

Fractal aspects of the flow and shear behaviour of free-flowable particle size fractions of pharmaceutical directly compressible excipient sorbitol

Hana Hurychová1, Václava Lebedová1, Zdenka Šklubalová1,*, Pavlína Dzámová1, Tomáš Svěrák2, Jan Stoniš1
1 Charles University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Hradec Králové, Czech Republic
2 University of Technology, Faculty of Chemistry, Institute of Materials Science, Brno, Czech Republic

Flowability of powder excipients is directly influenced by their size and shape although the granulometric influence of the flow and shear behaviour of particulate matter is not studied frequently. In this work, the influence of particle size on the mass flow rate through the orifice of a conical hopper, and the cohesion and flow function was studied for four free-flowable size fractions of sorbitol for direct compression in the range of 0.080-0.400 mm. The particles were granulometricaly characterized using an optical microscopy; a boundary fractal dimension of 1.066 was estimated for regular sorbitol particles. In the particle size range studied, a non-linear relationship between the mean particle size and the mass flow rate Q10 (g/s) was detected having amaximum at the 0.245mm fraction. The best flow properties of this fraction were verified with aJenike shear tester due to the highest value of flow function and the lowest value of the cohesion. The results of this work show the importance of the right choice of the excipient particle size to achieve the best flow behaviour of particulate material.

Keywords: flowability; size fraction; sorbitol for direct compaction; Jenike shear tester; fractal dimension
Grants and funding:

The authors thank to the grant No. 322315/2015 of Grant Agency of Charles University and the specific research project 260 291 of Charles University for the financial support.

Received: November 29, 2016; Accepted: December 1, 2016; Published: June 1, 2016  Show citation

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Hurychová H, Lebedová V, Šklubalová Z, Dzámová P, Svěrák T, Stoniš J. Fractal aspects of the flow and shear behaviour of free-flowable particle size fractions of pharmaceutical directly compressible excipient sorbitol. Čes. slov. farm. 2016;65(6):221-225. doi: 10.36290/csf.2016.043.
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