Influence of drug concentration and blending technology on the content uniformity of mixture for low dose warfarin tablets

Jan Elbl, Jan Muselík, Aleš Franc, Jana Mikušová, Zuzana Dolejší, David Vetchý

Čes. slov. farm. 2016, 65(6):211-215 | DOI: 10.36290/csf.2016.041  

Warfarin is a drug with narrow therapeutic index. Individualization of dose and thorough therapy monitoring is compensated by long time use in praxis and low therapy cost. Considering the low dose usually administered, critical parameter of solid dosage form is its uniformity of content. It has to not only meet the criteria set by pharmacopoeia, but to meet them on statisticall significant level also.This experimental study asseses impact of warfarin concentration and blending time after adition of lubricant on uniformity of content of mixtures and tablets made of them. It concludes, that concentration in 2-2,7% range is optimal and its increase...

Level of understanding of medical terms among italian students

Iolanda Grappasonni, Hana Klusoňová, Lenka Kračmarová, Fabio Petrelli

Čes. slov. farm. 2016, 65(6):216-220 | DOI: 10.36290/csf.2016.042  

Problems related to medical treatment and health literacy are nowadays a considerable difficulty, particularly if awareness of them is low. There is still a lack of information about students' understanding of medical recommendations. The aim of this work was to determine the understanding of medical terms among Italian students and to find out if there is any relation between understanding and age, gender, education or parental occupation. The research was realized via questionnaires in the Marche region of Central Italy in 2015. Students were chosen at random from grammar schools, vocational schools and the local university. 387 completed questionnaires...

Fractal aspects of the flow and shear behaviour of free-flowable particle size fractions of pharmaceutical directly compressible excipient sorbitol

Hana Hurychová, Václava Lebedová, Zdenka Šklubalová, Pavlína Dzámová, Tomáš Svěrák, Jan Stoniš

Čes. slov. farm. 2016, 65(6):221-225 | DOI: 10.36290/csf.2016.043  

Flowability of powder excipients is directly influenced by their size and shape although the granulometric influence of the flow and shear behaviour of particulate matter is not studied frequently. In this work, the influence of particle size on the mass flow rate through the orifice of a conical hopper, and the cohesion and flow function was studied for four free-flowable size fractions of sorbitol for direct compression in the range of 0.080-0.400 mm. The particles were granulometricaly characterized using an optical microscopy; a boundary fractal dimension of 1.066 was estimated for regular sorbitol particles. In the particle size range studied,...

Effect of EUDRAGIT^® RS on the release behaviour of theophylline solid dispersions

Oluwaseun Orugun, Avosuahi Oyi, Adeniji Olowosulu, Yonni Apeji, Olubunmi Olayemi

Čes. slov. farm. 2016, 65(6):226-231 | DOI: 10.36290/csf.2016.044  

The purpose of this study was to extend the release of theophylline using Eudragit^® RS 100 and Eudragit^® RSPO as carriers. Solid dispersions of theophylline were prepared by the solvent evaporation technique using Eudragit^® RS 100, Eudragit^® RSPO and their blend in various drug : polymer ratios. The prepared solid dispersions were characterized with respect to entrapment efficiency, solubility and recovery yield. In vitro drug release of theophylline from the solid dispersions was evaluated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes. Solubility...

42. lekárnické dni Lekárnickej sekcie SFS

Čes. slov. farm. 2016, 65(6):232-237  

Autorský rejstřík

Čes. slov. farm. 2016, 65(6):238-239