JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2014, 63(6):267-271 | DOI: 10.36290/csf.2014.050

Influence of excipients on caffeine permeation from gels

Alexandra Kodadová1,*, Zuzana Vitková1, Petra Herdová1, Jozef Čižmárik2, Monika Zsidová1
1 Katedra galenickej farmácie, Farmaceutická fakulta UK, Bratislava, SR
2 Katedra farmaceutickej chémie, Farmaceutická fakulta Univerzity Komenského v Bratislave, SR

The subject of this paper is a study of the influence of excipients on caffeine permeation from dermal semisolids drugs. Due to its advantageous properties, caffeine can be successfully used in dermal hydrogels. The choice of excipients from the group of humectants and cationic surfactants also plays an important role. The excipients should ensure long-term stability of hydrogels and the best permeation of the drug from gels. In particular, the influence of various excipients on caffeine permeation from gels and at the same time their influence on rheological properties of hydrogels were investigated. Based on the obtained results, the following optimal composition of caffeine gel was determined: 2.5 % chitosan + 0.1 % caffeine + 10 % propylenglycol + 0.1 % benzyldimethylhexadecylammonium chloride.

Keywords: caffeine; hydrogels; permeation; rheological parameters

Received: September 15, 2014; Accepted: November 13, 2014; Published: June 1, 2014  Show citation

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Kodadová A, Vitková Z, Herdová P, Čižmárik J, Zsidová M. Influence of excipients on caffeine permeation from gels. Čes. slov. farm. 2014;63(6):267-271. doi: 10.36290/csf.2014.050.
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