JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2011, 60(1):4-6

On teaching the chemistry of pharmaceutical auxiliary substances within the framework of pharmaceutical education in the Czech and Slovak Republics

Jan Šubert

The paper emphasizes the need of the introduction of the subject Chemistry of Pharmaceutical Auxiliaries into the Pharmacy study programme at more colleges in the Czech and Slovak Republics. It also introduces and discusses some topics for possible extension of the content of the courses of the subject (the presented examples are taken form the field of analytical chemistry of pharmaceutical auxiliaries).

Keywords: chemistry of pharmaceutical auxiliaries; education

Received: December 15, 2010; Accepted: January 7, 2011; Published: January 1, 2011  Show citation

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Šubert J. On teaching the chemistry of pharmaceutical auxiliary substances within the framework of pharmaceutical education in the Czech and Slovak Republics. Čes. slov. farm. 2011;60(1):4-6.
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    References

    1. Melichar, B., Čeladník, M., Hartl, J., Chocholoušová, J., Kňažko, L., Nováček, L., Palát, K., Sova, J., Vanžura, J.: Chemická léčiva. 3. vyd. Praha: Avicenum 1987; 985 s.
    2. Beneš, L.: Osobní sdělení, 2001. Go to original source...
    3. Farmaceutická fakulta v Hradci Králové: Sylabus předmětu Farmaceutická chemie. http://www.faf.cuni.cz/studium/magisterske/farmacie/sylaby/kfchkl/Stranky/sylab_farm_farmaceuticka_chemie.aspx (27. 11. 2010).
    4. Univerzita veterinárného lekárstva a farmácie v Košiciach: Informačný list predmetu Farmaceutická chémia, Sylabus predmetu (dátum poslednej úpravy 28. 9. 2010).
    5. Farmaceutická fakulta UK v Bratislave: Farmaceutická chémia - Stručná osnova predmetu. http://www.fpharm.uniba.sk/index.php?id=2544 (8. 12. 2010).
    6. Šubert, J.: Návrh nového povinně-volitelného předmětu Chemie farmaceutických pomocných látek. Zasláno vedení Farmaceutické fakulty VFU Brno dne 27. 4. 2006.
    7. Farsa, O.: Pharmaceutical excipients from the point of view of a medicinal chemist. Khimija 2009; 18, 165-171. http://khimiya.org/pdfs/EKHIMIYA_18_5_FARSA_L.pdf (27. 11. 2010).
    8. Šubert, J., Čižmárik, J.: Application of instrumental colour measurement in development and quality control of drugs and pharmaceutical excipients. Pharmazie 2008; 63, 331-336.
    9. Wou, L-S., Mulley, B. A.: Effect of dispersion on the coloring properties of aluminum dye lakes. J. Pharm. Sci. 1988; 77, 866-871. Go to original source... Go to PubMed...
    10. Soriano, M., Melgosa, M., Sánchez-Maranón, M., Del-gado, G., Gámiz, E., Delgado, R.: Whiteness of tal-cum powders as a quality index for pharmaceutical uses. Color Res. Appl. 1998; 23, 178-185. Go to original source...
    11. Šubert, J., Farsa, O., Cieslarová, M.: Efficiency of stabilization of low level of coloration of Castellani's paint without fuchsine with disodium edetate. Pharmazie 2006; 61, 1049-1050.
    12. Schulz, R., Gerhards, R.: Optimization of the potentio-metric titration of ionic detergents. International Laboratory 1994; 24, 10-14.
    13. Schulz, R.: Titrimetric determination of surfactants and pharmaceuticals. Herrisau: Metrohm 1999; 242 s.
    14. Thoma, K., Ullmann, E., Loos, P.: Zur Gehalt-bestimmung grenzflächenaktiver quartärer Ammo-niumverbindungen (Invertseifen) mit Hilfe Flockungsreaktion. Arch. Pharm. 1963; 296, 417-420. Go to original source... Go to PubMed...
    15. Mizuguchi, H., Yasuda, H., Kaneko, E., Yot-suyanagi, T.: Drop based visual fluorometry of aluminium at ppb level with 2,2'-dihydroxyazobenzene by using octadecylsilanized silica thin layer. Chem. Lett. 1997; 895-896. Go to original source...
    16. Mizuguchi, H., Kaneko, E., Yotsuyanagi, T.: Visual fluorimetry of trace aluminium by specific immobi-lization with o,o'-dihydroxyazobenzene on an octade-cylsilanized silica thin layer. Analyst 2000; 125, 1667-1671. Go to original source...
    17. Český lékopis 2009, 1.-3. díl. Praha: Grada Publishing 2009; 3942 s.
    18. Adeloju, S. B., Bond, A. M.: Influence of laboratory environment on the precision and accuracy of trace element analysis. Anal. Chem. 1985; 57, 1728-1733. Go to original source... Go to PubMed...
    19. Caraballo, I., Rabasco, A. M., Fernández-Aré-valo, M.: Study of thiomerosal degradation mechanism. Int. J. Pharm. 1993; 89, 213-221. Go to original source...
    20. Tan, M., Parkin, J. E.: Route of decomposition of thio-mersal (thiomerosal). Int. J. Pharm. 2000; 208, 23-34. Go to original source... Go to PubMed...
    21. Šubert, J., Farsa, O., Marečková, M.: Stability evaluation of methylparaben and propylparaben in their solution Aqua conservans using HPLC. Sci. Pharm. 2007; 75, 171-177. Go to original source...
    22. Thompson, M. J., Fell, A. F., Clark, B. J., Robin-son, M. R.: LC studies on the potential inter-action of paraben preservatives with sorbitol and glycerol. J. Pharm. Biomed. Anal. 1993; 11, 233-240. Go to original source... Go to PubMed...
    23. Hensel, A., Leisenheimer, S., Müller, A., Wolf-Heuss, E., Engel, J., Busker, E.: Transesterification reactions of parabens (alkyl 4-hydroxybenzoates) with polyols in aqueous solution. J. Pharm. Sci. 1995; 84, 115-118. Go to original source... Go to PubMed...
    24. Ma, M., DiLollo, A., Mercuri, R., Lee, T., Bun-dang, M., Kwong, E.: HPLC and LC-MS studies of the transesterification reaction of methylparaben with twelve 3- to 6-carbon sugar alcohols and propylene glycol and the isomerization of the reaction products by acyl migration. J. Chromatogr. Sci. 2002; 40, 170-177. Go to original source... Go to PubMed...
    25. Blanco, M., Coello, J., Iturriaga, H., Maspoch, S., Romero, M. A.: Resolution of isomers of sorbitolparaben esters by chromatographic and electrophoretic tech-niques. J. Chromatogr. B 2001; 752, 99-105. Go to original source... Go to PubMed...
    26. Kalász, H., Antal, I.: Drug excipients. Current Medicinal Chemistry, 2006; 13, 2535-2563. Go to original source... Go to PubMed...
    27. Souhrn údajů o přípravku Differine krém. http://www.leky.sukl.cz/modules/medication/detail.php?code=0046643&tab=texts (6. 12. 2010).
    28. Souhrn údajů o přípravku Excipial U Lipolotio. http://www.leky.sukl.cz/modules/medication/detail.php?code=0016462&tab=texts (6. 12. 2010).
    29. Souhrn údajů o přípravku Micetal gel. http://www.leky.sukl.cz/modules/medication/detail.php?code=0053904&tab=texts (6. 12. 2010).

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