Čes. slov. farm. 2009, 58(1):14-20

A study of the properties of compacts from directly compressible fructose

J. Mužíková^*, S. Lišková

Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology

The paper deals with a study of tensile strength and disintegration time of compacts from directly compressible fructose Advantose FS 95 and its mixture with microcrystalline cellulose Vivapur 102 in the ratio of 1:1 in dependence on compression force. It examines the effect of an addition of two lubricants, magnesium stearate and sodium stearyl fumarate, in the concentration of 1%, and an addition of active ingredients, ascorbic acid and acetylsalicylic acid in the concentration of 50%. In the case of Advantose FS 95, no statistically significant difference was observed in the values of strength of compacts within the type of the lubricant employed with an exception of the compression force of 10 kN, where the strength of tablets was lower with sodium stearyl fumarate. Compacts from the mixture of Advantose FS 95 with Vivapur 102 had a higher strength. Its values were markedly decreased by the action of lubricants, more in the case of magnesium stearate. Disintegration time of tablets in the case of Advantose FS 95 was prolonged more by magnesium stearate and in the case of the mixture of dry binders, sodium stearyl fumarate. Tablets with acetylsalicylic acid had a significantly higher strength and also a longer disintegration time than those with ascorbic acid.

Keywords: Advantose FS 95; Vivapur 102; lubricants; tensile strength of tablets; disintegration time of tablets

Grants and funding:

The study was supported by the grant MSM 0021620822 and by the firm SPI Pharma group and J. Rettenmaier & Söhne GmbH + Co, which supplied the samples of the dry binders tested.

Received: November 5, 2008; Accepted: December 20, 2008; Published: January 1, 2009  Show citation