JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2007, 56(4):183-189

A study of the properties of tablets from the mixtures of directly compressible starch and directly compressible lactitol

J. Mužíková, J. Vajglová
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

The paper deals with the evaluation of tablets from the mixtures of directly compressible starch Starch 1500® and directly compressible lactitol Lacty®-Tab in a ratio of 3:1 and 1:1. The examination included the tensile strength and disintegration time of tablets in dependence on compression force, addition of two concentrations of sodium stearyl fumarate (Pruv) as the lubricant, and a 50% content of the model active ingredient acetylsalicylic acid. Tensile strength of tablets increased with compression force and the effect of Pruv decreased it in both mixtures. Tablets from the mixture of dry binders in a ratio 1:1 without the lubricant possessed highest values of tensile strength. After an addition of the lubricant, no statistically significant difference was found in this mixture between interventions of 0.5 and 1% Pruv concentrations into strength. Disintegration time increased with compression force; it was the shortest in tablets with 1% Pruv in the case of the mixture of Starch 1500 and lactitol 3:1; in the case of the mixture 1:1 it was the longest. Tablets containing acetylsalicylic acid possessed higher values of tensile strength in the case of the mixture of dry powders in a ratio of 1:1, the strength decreasing with increasing Pruv concentration. Tablets from this mixture also possessed a longer period of disintegration time which increased with increasing Pruv concentration.

Keywords: Starch 1500®; Lacty®-Tab; sodium stearyl fumarate; acetylsalicylic acid; tensile strength of tablets; disintegration time

Received: March 28, 2024; Accepted: June 14, 2024; Published: April 1, 2007  Show citation

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Mužíková J, Vajglová J. A study of the properties of tablets from the mixtures of directly compressible starch and directly compressible lactitol. Čes. slov. farm. 2007;56(4):183-189.
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