474
1221912100974177118
|34921009720
ČESKÁ426804001075194139184242
A6908040010753
SLOVENSKÁ764804001074283142189234293335381439
FARMACIE1224804001074291139211266317337381
/16518040010731
Čes.1727804001075194128144
slov.1891804001073452101141153
Farm.2063804001074279105180196
2026;75(2):122-1262279804001074487128170185227268290332355369406444488513552589632
/29568040010731
www.csfarmacie.cz48348040010765133201214254289314356382457497538556600615655694
SAMOLÉČBA4262000984294163222264307356404456
Mykózy4253200956298133175207245
nohou6883200954386130173216
–92232009540
léčba979320095175794138175
volně1172320095367896139179
prodejnými13683200954469111156195212255290356373
přípravky1759320095446885130154191227262300
na20773200954379
základě21743200953270104123159203243
klinických2434320095345369112129165199238273316
doporučení27683200954387132176200243279317361377
https://doi.org/10.36290/csf.2026.0224254300954367951391691832142376594300974590109768430095145781125154920430097417996140181221262305331364398422438481522562602619661701742
Mykózy4259300277190308435561666788
nohou12579300277131260392521652
–19529300277110
léčba2106930027764182282418537
volně26879300277121246310441560
prodejnými3290930027713422335248660467180391711091173
přípravky42511900277134223285420508626742867992
na146111900277132252
základě175611900277107229355421541675793
klinických2592119002771271932573884525516788038981031
doporučení36671190027713426339652661474384296010931156
Ivana425157001373190147212270
Kuklová7181570013767129189221285341399
Dermatovenerologická42517200133731291652563093444034545085696246597197458058678929419911045
klinika1494172001335178103163188239293
VFN18101720013361115185
v20191720013353
Praze2095172001335893146193248
Tinea425223001214973126175222
pedis6632230012156106161183221
(atletická901223001212871102125173206228271316364
noha)12812230012155108162209234
představuje1531223001215688136192230262310355409431480
povrchovou20282230012156110156188231284338383436489
mykotickou25342230012182126172224256278321366418472
infekci3022223001212377105153199241263
kůže3302223001214699141189
způsobenou3508223001214297151189242298347401455508
dermatofyty,40332230012155104136217264295348376425460508524
nejčastěji45732230012155104126170217255287335358380
antropofilním49692230012148101133164217272327355380402455478559
dermatofytem4252370012156107140223271304358387438474524607
Trichophyton105723700121477496138191243296350392425476530
rubrum.160823700121328513716922230219092370012121
Klinicky1955237001215479102157180225271322
se2302237001214090
projevuje2417237001215790145168219266322346396
zejména2838237001214393117200251306354
deskvamací,32182370012156106146192243292375423468491512
erytémem3755237001215083133170219302353436
a42172370012148
tvorbou4286237001213384138171228283339
ragád,4650237001213381137185242263
přičemž4938237001215790113158207290333
může52962370012184138181231
nabývat4252510012155104160207258307339
tří78325100121336589
základních890251001214393139165212269324348392447
forem:1356251001212984117167250270
interdigitální,1645251001212378111160193249272328351384433457512535555
plantární2219251001215781129184217265298354377
a26142510012149
vezikulobulózní.2684251001214897140164210266289344401457480535577633656676
Infekce3379251001212479108159206249298
bývá36962510012157103155203
provázena3918251001215790144191240283333389437
mírným43732510012184107140196241325
pruritem;4717251001215790145178201234283367386
při5122251001215790113
vzniku5254251001214893148171218273
ragád425265001213381137185242
se688265001214090
často799265001214594133167221
přidávají1041265001215790113170218264313336360
pálení14222650012157105129179235258
a17012650012148
bolest.17712650012156112136187226260281
Macerace,4252790012180129174223256304349398418
ragády863279001213381137185242290
a11732790012148
deskvamace12422790012157107146193244293376424469518
stratum1780279001214073106154187242325
corneum2125279001214599132188238293376
v25222790012148
meziprstních25912790012183134177201257290331364420443488543
prostorech3154279001215790144183217271304354400455
mohou36292790012183139194250305
zároveň3954279001214393125180227276332
sloužit4306279001213963118173216239272
jako4599279001212472119172
vstupní4792279001214887121176233288311
brány5124279001215789138193239
pro5383279001215790144
β-hemolytické425293001215689145196279335359406442465510557605
streptokoky,1058293001214074106156213246300347401448499515
což1600293001214599141
zvyšuje1769293001214394144184238262312
riziko210929300121335699122169223
rozvoje2359293001213388130180234258308
erysipelu.2695293001215083133173196253304328382403
Další31262930012167114138177200
komplikací33542930012146100184241265288334383428451
je3833293001212474
možnost39352930012184139181236291331365
šíření432729300121406398148204227
infekce4581293001212479108158205249298
na49072930012155103
nehty,50382930012155106162194244260
ruce,5326293001213288133182202
třísla42530700121336689128151199
či645307001214568
jiné734307001212548103153
části909307001214493132166189
těla.1119307001213383106154176
Tinea425321001215075130180228
pedis6783210012157108165189228
je931321001212474
primárně1030321001215790114197245277333384
indikována1439321001212378135158205258305354409457
k19213210012147
lokální1989321001212479126176199254277
antimykotické22913210012148104136159242288335389422445490536585
terapii.2901321001213382115164220244267288
Mezi32143210012180131174198
volně34373210012148102126181231
prodejná3693321001215790145202252276331379
antimykotika40973210012149104136159242288335389422445492541
patří46633210012157106138170194
zejména4882321001214393117200250306354
imidazoly,52613210012123106130186234425335001214398122169185
allylaminy,63033500121487194142166214297320376421437
thiokarbamáty1087335001213388111166213263295352401484532565615
a17213350012148
deriváty17913350012156106139163211260292342
kyseliny2153335001214797136187211234289335
undecylenové.25073350012155111167218263313337387443498545594615
Na31413350012166114
základě3275335001214393140165213269319
analýzy36143350012148104152175222268318
klinických395133500121477295150174218265315359414
studií4385335001213973128185208231
byla46363350012157103127175
porovnána48313350012157113146200247304352407455
jejich530633500121247498121166221
účinnost4253490012155100123178233288328361
i8083490012123
délka8523490012157107131177227
léčby.1100349001212374119176222239
Klíčová425366001235885111155211261312
slova:758366001234268124174225248
tinea1027366001213356111162210
pedis,12583660012157108165189228249
dermatofyty,15283660012156107139223271304358387438474524540
Trichophyton208936600121477496138191243296350392425476530
rubrum,2637366001213284137169221302323
léčba,2979366001212474120176225246
allylaminy,324636600121487295142166214297321376421437
imidazoly.37053660012123106129186234277332356403420
Foot4253920015165131199242
mycoses68539200151104164213281332393445
–11483920015160
treatment1225392001514693155218260362424494536
with17793920015192124167237
over-the-counter20343920015171132191237274318388449489543611679748791853899
preparations29503920015174119181252315360421464497564633684
based36523920015173136187249320
on39893920015171140
clinical4147392001515487119188220271334366
recommendations45313920015149110162230331433495564634697740773840909960
Tinea425411001214974129179226
pedis6694110012156107164187225
(athlete’s912411001212873105160183233266315335371
foot)1304411001212984139171198
is1520411001212362
a15994110012148
superficial1668411001213993149200233264290335357405428
fungal2113411001212985140195243266
skin2397411001213985110164
infection2579411001212378107156202237259314369
caused2966411001214492147185236292
by32764110012156102
dermatophytes,33964110012156106138222269301355412467512548597636657
most40704110012183138177210
commonly4298411001214598181263318373396443
the4759411001213388138
anthropophilic49144110012148103135189222276332388444500523546568613
dermatophyte4254250012156107140223271304358415471517553602
Trichophyton105242500121477496138191243296350392425476530
rubrum.160342500121328513716922130219044250012121
Clinically,1950425001215881104159182227275299322369385
it2360425001212457
is2442425001212363
characterized25304250012144100148180229273309358391414457507564
mainly31204250012183131154209233280
by34254250012157104
scaling,3554425001213984133156179235291311
erythema,3891425001215082133169224275358406427
and43444250012148103160
fissure452942500121295594133188220270
formation,4824425001212984117201249282305360416436
and52854250012149104161
it5471425001212356
may4254390012183132177
present629439001215790140179230285318
in973439001212479
three1079439001213388120170221
primary1327439001215790113196245277327
forms:1681439001212984117201240260
interdigital,1968439001212379111160193249272328351385433457477
plantar,2472439001215781129184217266298314
and28134390012148103160
vesiculobullous.3000439001214897136159204259282337394450473496551607646667
The36944390012150106157
infection3877439001212479108158204239262317373
is4277439001212362
often4366439001215584121170225
accompanied4618439001214893137191274331380435458508566
by52104390012157104
mild53404390012184107130187
pruritus;425453001215790145178201234289329348
when7944530012174130180236
fissures105145300121295594134188220270310
develop,13824530012156107154203227283340359
burning17624530012157113145201224279335
and21194530012148103160
pain23004530012157106129184
may25054530012183132177
also2703453001214972111166
occur.28904530012155101144199232248
Maceration,4254670012180128173221254302334357411466487
fissures,92946700121295594133187219268307328
and12754670012147102158
desquamation14514670012156106145201255303386433465488543598
of2066467001215584
the2167467001213388138
stratum2322467001214073105153186240323
corneum2662467001214598130186236290373
in3053467001212378
the3148467001213388138
interdigital3303467001212378110159191247270325348381429452
spaces3773467001213995144188237276
may40664670012183131176
serve4259467001214090122173222
as4498467001214887
entry46024670012150105137169219
points48394670012156112135190222262
for5118467001212984117
β-haemolytic52524670012156881441922424254810012183139163210246269314
streptococci,765481001213973106156213246300345399445488511532
thereby1322481001213389139172222279325
increasing1673481001212378123156206254293316371427
the2126481001213388138
risk229048100121335695142
of2457481001215584
erysipelas.2567481001215083133173196252304328375415436
Another30294810012161116171204259310342
complication3397481001214598182239263286331379412435490546
is3968481001212463
the4056481001213388139
potential42204810012157113146195251283306354378
spread4623481001214096129179227284
of4933481001215484
infection5042481001212479108158204239262317373
to5440481001213387
the425495001213388139
nails,5854950012155103126150189210
hands,8164950012156104159215255276
groin,1113495001215688143166222242
or1377495001215487
other1486495001215487142193226
body17334950012157113170217
sites.197249500121396295145184205
Tinea425509001215074130180228
pedis6715090012157108165188227
is916509001212362
primarily996509001215790114197245277301324371
indicated1385509001212379135158203251284333390
for1793509001212984117
topical1928509001213387144168213261285
antifungal22315090012148103135158187243298354402426
therapy.2675509001213388138171220276322339
Over-the-counter30325090012169118167200227260316366399446500555611643692725
antifungal37755090012148103135158188243299355403426
agents42195090012148104154210242283
include4520509001212378123146201257308
imidazoles,48465090012123106129186234277331355406445466
allylamines,5330509001214872951421664255230012148131154209260299320
thiocarbamates,763523001213388111166211260292349398481529561611650671
and14525230012148103160
undecylenic16305230012155110166217262312336386442465509
acid2157523001214893116172
derivatives.23475230012157107140163211260292315363412452473
Based28385230012154103142192249
on31055230012155110
an32335230012149104
analysis33555230012148103151174221261284323
of3696523001215484
clinical379752300121456891146169214262286
studies,4101523001213973128184208258297318
their4437523001213388138162194
efficacy4649523001215080112138183232276326
and49935230012148103160
duration51715230012156110143191224247302357
of425537001215584
treatment530537001213366116164196279330386418
have9695370012156104150199
been11895370012157108159215
compared.1425537001214599182239288320370427448
Key4255540012358108158
words:6045540012374130166224266290
tinea915554001213356111162210
pedis,11465540012157108165188228249
dermatophytes,14165540012156107139223271304358415471516553602642663
Trichophyton210055400121477496138191243296350392425476530
rubrum,264855400121328413716922130229485540012121
treatment,2990554001213366115163196279330385418439
allylamines,345055400121487295142166214297321376426466487
imidazoles.39585540012123107130186234278332356407446468
Úvod4256050013977139203272
Dermatofytóza5656220010758103129203244271317341385416462497540
(synonymum112162200107245697146194242281355403476
tinea,161462100110325510615320018136220010716
odvozeno1845622001074898139186221264312361
od2222622001074898
latinského233662200107196087106153186224267315363
„červ,2716622001072666108134178189
larva“)42563600107195884127167192218
představuje658636001074975117166198226266305352370413
nejčastější1087636001074790108147187220248289307339356
mykotické14596360010773110148194220239278315357
onemocnění1831636001074795138210257297344387434452
kůže,2299636001073784120161175
vlasů249063600107405998131176
a26826360010740
nehtů2740636001074891138425650001072876
u5206500010748
lidí58865000107193786105
i7136500010719
zvířat.751650001073780100129170198214
Je985650001073175
způsobena1080650001073686134167215266310359399
keratinofilními1499650001073881108149176195243291315335354402420494512
houbami2031650001074897145194236310328
–23796500010745
dermatofyty,2444650001074993119193234261308332376407449461
které425664001073869111138181
mají6236640010774114133152
schopnost792664001073374122170221269318351380
rozkládat1189664001072774109148168209258299326
keratinizované1532664001073881108149176195243262298345386427475519
tkáně.2068664001072866109157201215
Keratin2300664001074588115156184202250
je2567664001072063
bohatý2647664001075099148189216258
na425678001074889
cystein.540678001074083117146188207255271
Dermatofyty8376780010758103130204245272319343386418460
vylučují1323678001074184104152192240259277
siřičitan,16266780010734527897138156184225274289
který1941678001073869112138181
působí2149678001074997130179229248
jako242367800107196098145
redukční2594678001072770120167205245293311
činidlo425692001074159108127177196245
a6976920010741
prostřednictvím759692001075078125159189216260310359378419450494514589
enzymu1375692001074493130174250298
cystein-dioxygenázy1700691001104189128161208232285315371395447492540593640694740782831
štěpí2558692001073463106157176
cysteinové2761692001074184118304760800107287089137185226269
vazby.3334608001074082119169209221
Tento3573608001074180128155202
proces,3792608001075077124165208241257
nazývaný4067608001074889126169214255303342
sulfitolýza,442760700110388911214216820025027432036341048376080010716
usnadňuje4870608001074881129170219267314333377
následnou52656080010748891221411852353047622001074897145
extracelulární3218622001074484114141183223266285333351392418467486
degradaci3730622001074993143170211261302342361
keratinu4117622001073881108149177195243291
rozsáhlou4434622001072774109145187235254302350
škálou4811622001073371113132180229
endoproteáz5066622001074492141190240267314341384424461
a30476360010742
exoproteáz.3109636001074585133185212261289332373411429
Tyto3565636001074378110158
enzymy3750636001074594132176252292
jsou4069636001071953102152
důležitými4248636001075098117162200220249293369388
determinanty4663636001075095124167195270290339380429457501
virulence519163600107416188138157202252293337
a30476500010741
zároveň3108650001073678104152192235283
mohou34116500010773122171219267
působit3698650001075098131179229248276
jako399465000107196098145
alergeny4159650001074159103130178222270309
(1,448865000107236374
2).458165000107446680
Keratinázy3187664001074588114156183202250290328371
uvolněné3574664001074889137156204248296340
v39316640010740
počáteční3991664001075099140181208251292340358
fázi4366664001072466103122
infekce450566400107196790133171211253
fungují4775664001072372120170217236255
optimálně5046664001074898126145218259277325369
při543266400107507695
kyselém3047678001073881114158177221295
pH,33586780010750107122
zatímco3497678001073678105123197237283
jiné379767800107193885129
keratinázy,3943678001073880107148175194241282319362373
aktivní4333678001074078109127168217235
v45856780010741
pozdějších4645678001075098134182225244276294334382
fázích,5044678001072365102121161209224
pracují5285678001074976117158205224242
nejlépe3047692001074892111130174224268
při333469200107497695
vyšším,3447692001074184118151169243259
zásaditém3724692001073678112153203222250292366
pH.41086920010750107123
Tento4249692001074281129156202
dynamický4470692001074989138179252271311349392
proces4880692001075077124165207241
ukazuje,5139692001074886128166214233277291
že5448692001073779
doc.42574000954487124139
MUDr.581740009562112164189200
Ivana7997400095175391134170
Kuklová,98774000953982116134177214251265
CSc.127074000954584120135
Dermatovenerologická42575200955292116182219243285321360403443467509527570615632668702740
klinika11827520095345369112129163201
VFN140175200954079129
v1547752009537
Praze160175200954063101134173
Ivana.kuklova@vfn.cz4257640095175491134170185220264298316359396433491528553597612648682
Cit.42207410095466388103
zkr:43407410095336792108
Čes.446574100954684114130
slov.46127410095304790126137
Farm.47677410095377094160175
2026;75(2):122-126496074100953977114152166203240260298318332365399438461496530568
Článek45237530095466399142182216
přijat47567530095456986103139164
redakcí:493775300952462107144178213230243
18.51987530095397489
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přijat45737650095456986103139164
po475476500954488
recenzích:48607650095246299137180214231267310323
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