340
Pharmaceutical8224570023711322432640256466775185196410361092117712801334
care21944570023785188263364
in25954570023755168
self-medication:2800457002378518624231137253763875480989399710671123123413461397
ABC/VED423445700237127244355416547650784
analysis82248000237103215318372474557612696
of155648000237111178
over-the-counter17724800023711121030738444651963373480088999911111224129413951472
antiallergic328148000237103215286342445500554655732843898983
medicines430148000237164265381436520576688789874
Viktoriia822512001176086137174228264290315365
Oleksiivna1206512001176895144196239265291341397447
Shapovalova¹,16725120011750106155212266315365390445494543567587
Oleksandr2278512001176794144196239289344400437
Ananiyovych27345120011761116166221247296349398450491547
Nevzhoda²,33005120011765115164209265320377427460481
Alina3800512001176287113168218
Olexandrivna4037512001176894144194243299355391416466522572
Osyntseva³,46285120011767108158214248289339388438469488
Valentyn8225250011760107133183238272324379
Valeriiovych12205250011760107133183219245271325374426467522
Shapovalov¹,17615250011751106156213267316365391446494521540
Valerii23205250011760107133183219245271
Volodymyrovych26105250011760110136191248297379426463517566618659715
Shapovalov³33445250011750106155212267315365391445494529
¹Soukromá822538001142370121173217248299378422
vědecká1264538001144691145192234278324
instituce1608538001142273110141162193244286332
„Výzkumná1960538001143381126168212264341393438
univerzita24185380011452103125170216246288310340386
medicínského28245380011478125179200242263315351395440493544
a33885380011445
farmaceutického3453538001142873104182227269314366397418460503549601652
práva“,4125538001145484130173218250264
Kyjev,4409538001145191113160205219
Ukrajina46485380011461104136181203225276321
1Private82255200662884855100114507999144188217262
Scientific1128551001144788108154205234254281304345
Institution1491551001142273109139160189240269290340391
“Scientific1900551001143480121141187238267288314337378
and2296551001144596148
Research2462551001145197133179223252292343
University28235510011461111132176221250287307337382
of3224551001145177
Medical33195510011476122175196236281302
and3639551001144596148
Pharmaceutical38055510011450100143173250294335380430460480521566586
Law”,4410551001144489156190202
Kyiv,4630551001145190111155169
Ukraine48175510011461103134178199249295
²Národní822564001142992137167218272323345
lékařská1187564001142269113159189227270316
univerzita15235640011452104125170216246288310340386
Danylo19295640011463107159201224275
Halytskyi22245640011462107128173207244288335357
Lvov,2601564001144485135179194
Lvov,2815564001144485135179193
Ukrajina30285640011461105136182203225277321
2Danylo8225770066288515770011463107159201224275
Halytsky11465770011462107128173207244288335
Lviv1501577001144485107152
National16735770011462107137158210262307328
Medical20215770011476123177198240286307
University,23485770011461112134179225255293314345391406
Lvov,2774577001144485135179193
Ukraine29875770011461105136182203255302
³Soukromá822590001142976128180223255306384429
vysoká1271590001144593129181225271
škola1562590001143781131153198
Lviv1780590001144485107152
Medical19525900011476123177198240285307
University,22795900011461112133178224255292313344391405
Lvov,2704590001144585135179194
Ukrajina29185900011461104136181203225276321
3Lviv822603006628851602001144485107152
Medical10236020011476123177198240285307
University,13506020011461112133178224255292314344391405
Lviv,1775602001144585107152167
Ukraine19626020011461104136181203254301
Introduction:82264600105237310313418423528432435737942847813016460010318
The1341646001034392136
growing1499646001034877124187209257305
prevalence1827646001034978121163205226270318358400
of2250646001034773
allergic234564600103416283127156204225264
diseases2632646001034868103147189223267302
and2956646001034190139
the3117646001032977121
widespread3260646001036384133177212261290334376425
use3707646001034882126
of3855646001034773
over-the-counter3951646001034788131160184214262306335376423471519548591620
(OTC)4593646001032583125174200
medicines48156460010371116165186225246294338372
necessitate822658001034791131174209243264293335364407
rationalization124965800103287099119167216258279299337380409429477526
of1795658001034772
symptomatic1887658001033476149199228275347389418438478
treatment,2384658001032957101143171244288336365384
balancing2787658001034992112154203242262310359
clinical316665800103385980128148187230251
relevance343765800103287193136178220268308351
with3807658001036385114162
limited3989658001032040112133162205255
healthcare4264658001034791133154183231271313342385
resources.4669658001032872106154202231270313347366
Aim:8226700010554771519736700010318
To1013670001034385
evaluate1120670001034385127148196238266309
OTC14526700010359101150
medicines16456700010372116166186225246294338373
used2040670001034782126175
for2238670001032573102
symptomatic2362670001033476149198227274347389417438477
allergy286167000103426383127156205246
treatment3130670001032857100142171243287335364
through3516670001032977105153201250298
ABC/VED3836670001035399150182234277334
analysis4193670001034189131152193228248283
in4498670001032068
order4588670001034776125169198
to4809670001032875
identify4906670001032070113162190211237281
priority82268200103497899147176197226269
medicines11116820010372116165186225246294338372
and1503682001034290139
support1662682001033481130180229258289
pharmaceutical1971682001034998140168241283322365413442463502544565
and2556682001034189139
managerial27156820010371113161203252296325346387408
decision-making.3143682001034892132153187207255304332405447488510558607626
Materials8226940010571116146191223245290313349
and1193694001054494144
methods:1360694001057211814919924829933616976940010318
The1737694001034392136
study1896694001033464111161202
included2121694001032068107128176225269319
252463694001034488
OTC25746940010359101150
medicines27466940010372116166186225246294338373
registered3141694001032872121142176206249278322371
in3535694001032068
Ukraine3626694001035596126168189237281
for3930694001032573102
symptomatic4055694001033476148198227274346388417438477
allergy455569400103416282126155204245
treatment4823694001032957101143171243287336364
during822706001034896125146194243
2024–2025.1083706001034488131173219260304346391408
Aggregate15107060010352100149178221271313341384
sales191370600103347798142176
data2108706001034991119162
from2289706001032554102174
pharmacy2482706001034998140168241283322365
networks2866706001034892121187234263304342
and3227706001034189138
distributors3384706001034969104133162183232280310357386421
were38247060010363106135179
analysed.4022706001034189131152193228272322341
ABC4382706001035299149
analysis4550706001034290132153194229249284
was48537060010362105139
used5011706001034782126175
to822718001032875
assess914718001034175109153187221
expenditure1152718001034384133177226275295324371400443
distribution,1612718001034868102132161181230278307327375423442
while20717180010362111131152195
VED2283718001034891148
analysis2448718001034188130151192226247281
classified2745718001033959101135169189215238281331
medicines30937180010371115164185223244291335369
according3479718001034180118165193242263310359
to3855718001032875
clinical394671800103395979127148186229249
importance4212718001032092141189218249291339378421
based4650718001034890124168218
on4885718001034695
pharmacist49967180010349971391678227300010371112151171205235
protocols,1073730001034977124153200239285307340359
clinical144973000103385878126146185227247
guidelines,1713730001034895115164207228249296340374393
pharmacological2122730001034997138167238280319365386434483503542584604
role,274373000103287596139157
safety2917730001033376101144174217
profile,3150730001034977124150173193237254
and3421730001034188137
suitability3575730001033480101130172221241262282311354
for3946730001032472100
self-medication.406373000103347798124150222266315335374416444465512560579
The4659730001034290134
integrated481073000103196795138187215257285328377
PLNÁ5407440018990171278381
VERZE95474400189101186283376463
ČLÁNKU➜14497440018991173279386486594207774500224139
https://doi.org/10.36290/csf.2026.02422497450017880123172253307330385424266474400181851662002861745001782610414722527831337440018177145174254328401475552600659719763788868941101310861116119212631334
POUZE5407630014564151233301364
PRO9377630014564132219
PŘEDPLATITELE11907630014564131195279347407487543577642706766829
ČASOPISU20537630014570149214301370401464544
ČESKÁ26317630014569132196264347
A30117630014574
SLOVENSKÁ31197630014559119203273337420483552634
FARMACIE37877630014558130198300378449481544
Justification8227800237811932783494054745296147177878449541066
of19257800237111179
a21417800237103
medicinal22827800237164265380435520575688790845
form3164780023768178254416
development3617780023711521631641446958069485895910721143
based82210100237115217301402518
on137710100237111223
the16381010023772186287
api196210100237103217272
dimethylammonium2271101002371151703344355076217197748771040120413141426148115931756
3-methyl-2-(2-((e)-styryl)quinazolin-4-ylthio)82212300237108171337438510624722777841941100110651167122712901345143914951559164517161821189720022057211522292341239525082610270228122867292130343098321132803380343535083622367637863842
butanoate82214500237115227299402514625727798899
with175814500237145199271385
hepatoprotective218014500237113214329432502613727802913984108611711245130114041501
and371914500237103215329
antioxidant4085145002371032162863424535516067218249361007
effects82216700237101170241341427501586
for14451670023769179254
the17361670023772186287
needs206116700237112213315431515
of261416700237111178
military283016700237164218273327399503578684
medicine355116700237164265381436520576688789
Antonina8222000011762116151205260286341391
Avramenko¹,12322000011762109145194276326381432486510529
Andrii17802000011762117173209235260
Kaplaushenko¹,20592000011758108165191241296337392442498549602626646
Volodymyr27242000011760110137191248297379427463
Salionov²32062000011751101127153207262317366401
¹Department822213001142386133187232262296374421473503
of1345213001145179
Physical,14432130011451101144181202243289310329
Colloidal,17922130011455105127149200222275319341360
and2172213001144597150
Analytical23422130011457109154175220254275316362384
Chemistry,27462130011454105152231252288320350397412
Zaporizhzhia822226001145298151203234256295347387439461505
State1347226001144776121152197
Medical15642260011476124177199240286307
and1891226001144697150
Pharmaceutical20612260011450101146176254299341387438469490532578599
University,26802260011461112134179225255293314345391406
Ukraine31062260011461104136181202254301
²Department822239001142993140193239269303381428480510
of1352239001145178
Clinical145023900114557697149170212257279
Laboratory1749239001144491144196226272302352383430
Diagnostics2199239001146384129181233284321352374415453
and2672239001144697150
Biochemistry,2842239001145173124167218265344365401433463510525
Zaporizhzhia822252001145298151203234256295347387439461505
State1347252001144776121152197
Medical15642520011476124177199240286307
and1891252001144697150
Pharmaceutical20612520011450101146176254299341387438469490532578599
University,26802520011461112134179225255293314345391406
Ukraine31062520011461104136181202254301
Objective:822295001056011113417821724927131435811802950010318
The1219295001034290134
study1374295001033362109158199
aims1594295001034161132165
to1780295001032875
substantiate1876295001033380128162191233280308328368396438
the2335295001032976119
development2475295001034891132174195242291362405453481
of2977295001034772
an3069295001034289
oral3179295001034775117137
dosage3337295001034895129170218261
form3619295001032572101172
for3812295001032572100
military3933295001037292111131159201229272
medicine42262950010371115164183222241288332
based4579295001034890123167216
on4816295001034794
the4931295001032876119
API5071295001035297116
dimethylammonium822307001034868139182211258297318359430501548596616663734
3-methyl-2-(2-((E)-styryl)quinazolin-4-ylthio)butanoate,1578307001034471143187215262301322349389414439482506532553213030700103402174307001032452861151571862292502743223693894364775145615826016486767237527928138418889089559771025107211001142118912371278130613481365
which35623070010363110130168215
demonstrates3800307001034891163210257291320348389417459493
antioxidant4315307001034189116136183222242291332379407
and4744307001034188137
hepatoprotective4903307001034891140181209255822319001034977124152194233263283324366
activity.1206319001034180110130171191220262276
The1501319001034290133
molecule’s16533190010371118139182221268288331349380
physicochemical2051319001034996135169189227273312359402474494532574594
properties2663319001034877123172216244275294337371
and3052319001034289137
dissociation3207319001034968102135183222241282310330377424
constant3650319001033884131165194236283311
were39793190010363105133176
evaluated.4173319001034383125145192233261303352370
Materials8223310010572117147191223245290312348
and1195331001054493144
Methods:1363331001057211814919924829933616993310010318
Computer1742331001035097169219267296339368
modelling21343310010373121170214235256276324373
was25313310010364106140
used2696331001034882126176
to2897331001032976
assess2997331001034276110154189223
lipophilicity,324533100103204090138188237257277297336356385429443
physicochemical3713331001034998137172192231278317365409482502541584604
parameters,4342331001034992120162235279308351380415433
and4800331001034290139
ADME49643310010353111180224
characteristics822343001033885126154196234264306335355388417437475510
via1350343001034162103
the1471343001032876119
SwissADME16083430010342104124157191243300368411
service.2037343001033477105149169208250267
Drug-likeness2322343001035786133181208230249289331378422455489
was28293430010363105138
evaluated2985343001034384125145192233261303352
according3356343001034179117163191239259306354
to3728343001032875
Lipinski’s3821343001034060109129176209249271289320
Rule4159343001034693113156
of4334343001034772
Five.4424343001034261102144161
Conductometric4604343001034995143191238277307353425468497524545583
PLNÁ5403650018990171278381
VERZE95436500189101186283376463
ČLÁNKU➜14493650018991173279386486594207736600224139
https://doi.org/10.36290/csf.2026.02322493660017880123172253307330385424266436500181851662002861366001782610414722527831333650018177145174254328401475552600659719763788868941101310861116119212631338
POUZE5403840014564151233301364
PRO9373840014564132219
PŘEDPLATITELE11903840014564131195279347407487543577642706766829
ČASOPISU20533840014570149214301370401464544
ČESKÁ26313840014569132196264347
A30113840014574
SLOVENSKÁ31193840014559119203273337420483552634
FARMACIE37873840014558130198300378449481544