475
|514567008016
E151956700803365
PŮVODNÍ45986700823783125173220268287
PRÁCE49016700823776121161197
Anticonvulsant3120760079397595109139174210240276290315346382402
biotargets3536760079375287108139159195227248274
of38257600793553
digoxin:3893760079365087123151166201212
in41207600791450
silico41847600792539536797132
study4330760079254783119149
and44947600793066103
in46117600791450
vivo4676760079304475110
verification480176007930628297113129159190211225261297
https://doi40728600793656791161411521781974266850080387591
https://4072860079365679116141152178197
.org/10.36290/csf.2025.02143578600791147671031284484850080346680116150184218253275303331351364400434467502515550583614
Anticonvulsant85512700230124231300355437544653750858912994109412031272
biotargets216312700230112165272342443516625723793876
of307512700230108174
digoxin:328512700230112165274381477530640690
in8551490023053163
silico10541490023082136189242324431
study15211490023083152262373473
and203014900230100209320
in23861490023054163
vivo258514900230101154254358
verification297914900230101195269321388442524624693747854963
Vadym8551800011458104158206286
Tsyvunin1,1159180001145084133184238292317370152318100673015511800011424
Hanna15931800011463112166219268
Severina2,1879180001145098146193228253307355223418100673022651800011424
Sergii2307180001145098134187213238
Shtrygol’1,25631800011450103136172222275328353378293918100673029671800011424
Victoriya3009180001145884125160213248273321369
Georgiyants2,33971800011462111165200254279327375429462503390018100673039311800011424
Diana3973180001146489138192240
Shtrygol’3423218000114491031361712212743273523784608181006730
1Department8551940065278801930011061107159203233265341387437466
of1366193001105076
Pharmacology1462193001104898141171247290331380401452503546
and2028193001104494145
Clinical219319300110537494144165206250271
Pharmacy,2483193001104998142171247291332377391
National28931930011060104134154204255299320
University32321930011059109130174218248284305335380
of3632193001105076
Pharmacy,3727193001104998142171248291332377391
Ukraine41371930011060102133177197248293
2Department8552060065278822060011061107159203233265341387437466
of1368206001105076
Pharmaceutical1464206001104898141171247291331376426456476517561582
Chemistry,20662060011053102148224245281311341386400
National24862060011060104133154204255298319
University28252060011059109129173218248284305335380
of3224206001105077
Pharmacy,3320206001104998142171247291332377391
Ukraine37302060011059102132176197247293
3Department8552190065278822180011061107159203233265341387437466
of1368218001105076
Neurology,14642180011060106156185235257307358402416
Psychiatry,1899218001104984128167217238282311340386400
Narcology23192180011060104133173222243294345388
and2727218001104494146
Medical28922180011074120172192233277298
Psychology,3210218001104883127167217267288339390433448
School3677218001104586136186237258
of3955218001105076
Medicine,40512180011073119171192233253303349367
V.855231001105164
N.939231001106080
Karazin1038231001105094124168207228278
Kharkiv13362310011049101144174216239282
National16382310011060104133154204255298319
University,19772310011059109129173218248284305335380394
Ukraine23902310011060102133177197248293
One8552730010057103144
of1017273001004569
the1103273001002873114
promising1234273001004874119187206238256301347
ways15982730010061101138170
to1785273001002872
control1874273001003781127153179224243
multidrug-resistant21342730010070114133160178224250296341367394435467485517544584629655
epilepsy2807273001004188107125166213245284
may31082730010070109146
be3271273001004889
to3378273001002771
use,3467273001004577118134
in3618273001002065
addition3700273001004087133151178197241287
to4004273001002872
traditional409327300100285494140158185203248294333352
antiepileptic4462273001004085111130171217236254296342369387424
drugs4903273001004773118164196
(AEDs),855285001002473113166199218233
medicines11012850010070111158176212231276317349
from146328500100245196165
other1641285001004672117158185
pharmacological1839285001004793132158227266302346365410457475512551570
groups2422285001004773117162209241
–26762850010041
the2731285001002772113
so-called2858285001003378105143183202220261308
„non-antiepileptic”3179285001003075120166192231276302320361408427445486533560578614644
drugs.3836285001004773119164196213
Among40622850010051119164210256
such4331285001003377114159
drugs,4503285001004773119164196213
the4729285001002772114
cardiac4856285001003777103149167206243
glycoside855296001004665104139183215233279320
digoxin1196296001004765111156193212257
deserves1473296001004788120161188229269301
special1795296001003379120157176215233
attention.204929600100406695135180206225270315332
It2401296001002047
was24682960010061101132
established2621296001004173101140187206224256301342389
that3030296001002873112138
sub-cardiotonic3188296001003378124151190229255301320365391435481499536
doses3744296001004792124165197
of3961296001004669
digoxin4051296001004665111156192211256
exhibit4328296001004180125144190209236
both4584296001004793119164
their4769296001002772113132158
own49482960010045105151
anticonvulsant855308001004085110128164208253290335354385425469495
effect136330800100416591132168197
and1572308001004085131
have1716308001004684122161
been1890308001004789130175
shown2078308001003277122181226
to2317308001002871
enhance2401308001004287131170215251291
the2704308001002872113
anticonvulsant2830308001004085110128165208253290335354385425469495
potential3338308001004792118158203229247286304
of3655308001004569
classical373630800100375694126157175211250269
AEDs.4018308001005090143175191
However,4222308001005499158198237276303315
the4550308001002772112
mechanisms46753080010069110147191230275293324392423
of855320001004569
this93732000100277290121
action1071320001004076105123167213
and1297320001003984130
the1440320001002872113
probable1566320001004773118164203249268309
cerebral1888320001003777103143190216255274
biotargets2175320001004765110136176202247288314347
with2535320001006179106151
which26993200010061106124160205
these2917320001002772113144185
properties3115320001004773118164205232260279319351
of3479320001004569
digoxin3561320001004664110154191210254
may38283200010069108145
be3986320001004788
associated,4087320001004072103148185203241267307354370
remain4470320001002767136175193237
completely4720320001003881149195214255282322340379
unknown.855331001004691129176221280326343
Molecular12173310010067112131172210254273312338
docking1574331001004792129167187232278
of1871331001004669
digoxin1959331001004766111156193212257
to2235331001002872
the2326331001002873114
following245933100100246989107152212231276321
cerebral2800331001003777103144191217257275
biotargets3095331001004766111137177203249290317350
was34643310010061100132
performed:3615331001004889116142187213282323370386
GABAAR,4020331001005410414819742173370059304247331001004563
GlyR,4329331001005473112156175
mGluR5,45233310010069123142187231273288
AMPAR,48303310010051118161207250268
hBCATc,855343001004690138189224255272
mGlu8R,11433430010070123142187229274292
NMDA-GluN1,14513430010055121176224249304324368422460473
KCNQ2,1940343001004590144201241257
COX-122143430010048102146169205
and2436343001004085131
COX-2.25833430010048102147169207224
To2823343001004181
confirm2920343001003781127150171197266
the3202343001002873114
in3331343001011962
silico34073430010131486684119160
results3583343001002768100144163190222
in3822343001011962
vivo389834300101385693134
pharmacological4048343001004793132158227266303347366411457476512552570
studies4634343001003361106152170211243
under4893343001004691138179205
conditions855354001003780124170188214231276320351
of1219354001004567
acute1299354001003975119145184
bicuculline-induced1496354001004765101144180224242260278322362388407452497541577616662
seizures217035400100337391125169195234266
and2448354001004084129
pentylenetetrazole2590354001004788132157197216256301341367407433459497532576594634
kindling3237354001003858102147165183227272
in3522354001001963
mice3597354001006987123162
have3771354001004684121160
been3944354001004687128172
carried4129354001003776101127145185231
out.4373354001004589115132
It4517354001002046
was4575354001006199130
established471835400100417299138183202220251295335381
PLNÁ5123660018990171278381
VERZE92636600189101186283376463
ČLÁNKU➜14213660018991173279386486594204936700224139
https://doi.org/10.36290/csf.2025.02122213670017880123172253307330385424263636700181851662002832367001782610414722527831053670018177145174254328401475552600659719763788868941101310881116119212631331
POUZE5113850014564151233301364
PRO9083850014564132219
PŘEDPLATITELE11613850014564131195279347407487543577642706766829
ČASOPISU20243850014570149214301370401464544
ČESKÁ26023850014569132196264347
A29823850014574
SLOVENSKÁ30903850014559119203273337420483552634
FARMACIE37583850014558130198300378449481544
E106604450080336697
|791445008015
PŮVODNÍ85444500823783125173220268287
PRÁCE115744500823776121161197
The85345500793168101
management96945500795484120151187220275308344364
of134845500793553
vulvovaginal14164550079306680111146176207244258294324338
candidiasis:17694550079306196133147184198228253267291303
the20874550079205689
results21914550079195176112126147173
of237845500793654
survey24464550079256080113145175
in263545500791450
Lviv,26994550079305872103112
Ukraine28254550079427091122136172205
The85350500230104212310
management11995050023016026036946957767583593310431112
of234750500230108174
vulvovaginal25575050023010121026336346756466277182493310331086
candidiasis:36795050023083183292403456568621721803856939989
the8535270023070181279
results11685270023074172255364417487570
of177552700230107174
survey19855270023082191265368462559
in25805270023053163
Lviv,27795270023097189242342385
Ukraine320052700230128232308405458568666
Oksana8535590011466116158207261309
Horodnycha1,11805590011464117152205260314360400454502167655900673017055590011424
Tetiana1747559001145093127153201255303
Ryvak1*,2069559001145410315420225223195590067302348559001144261
Oksana24275590011466116158207261309
Nepyivoda2275555900114631121672132392883393944433197559006730
1Department8535720065278795710011061107159203233265341387437466
of1365571001105076
HealthCare14615710011059105149170200250303347376422
Management,19025710011074118168211262308384430480509528
Pharmacotherapy2450571001104898141171247291331380410460505535579631673
and3142571001104494146
Clinical330757100110537494144165206250271
Pharmacy,3597571001104998142171248291332377391
Faculty4007571001104585126176197226272
of4298571001105077
Pharmacy,4394571001104998141171247291331376391
Danylo8535840011061104155196218268
Halytsky11405840011060104125168201237280325
Lviv1485584001104382104148
National16525840011060104134154204255298319
Medical19915840011073119172192233277298
University,23095840011059109129173218247284305334380394
Lviv,2722584001104383104148162
Ukraine29045840011059101132176197247292
2Emergency8535970065278815960011045120166196246292343383428
Hospital13295960011060110146197218248292313
of1662596001105076
Lviv,1758596001104382104147161
Ukraine19395960011059101132176197247293
Vulvovaginal853639001004690110150195234274321340386426445
candidiasis1317639001003778124171190237256296329348380
(VVC)1716639001002372121168193
is1927639001002052
a19986390010040
serious2056639001003375102122168214246
clinical232163900100375675121140178218238
and2577639001004086133
social2729639001003278116135175195
issue.294263900100205285130172188
The3149639001004188130
questionnaire-based3297639001004793135167196215261307353393412439480508556597629671719
study4034639001003362107154194
was42466390010061102134
performed4399639001004789117144189217286328376
to4793639001002873
assess4884639001004073106147180213
the853650001002873115
management9846500010070110156196242284354396442469
of1469650001004670
VVC1555650001004696143
in1714650001002065
Lviv,179665000100397595135148
Ukraine.1960650001005493121162181227269285
Totally2261650001004282110150170189228
4082505650001004387130
women26516500010061107176218264
were29326500010061102129171
enrolled3119650001004188115160180199241289
in3424650001001965
the3505650001002874116
survey.3637650001003378105148188227241
The3894650001004188130
lifetime404065000100203963105133152221263
prevalence4319650001004875117156196216258304342382
of4717650001004670
VVC4803650001004797144
was49636500010061101134
high853662001004665112158
(72.61026662001002365107124168
%).1204662001006687102
35.8132166200100438399143
%14756620010065
of1555662001004670
women16406620010061106176218264
had1919662001004686133
VVC2067662001004696143
during2225662001004792119139185231
the2471662001002873115
last260166200100206092120
year2736662001003980120147
with2898662001006181108154
the3067662001002874115
predominance3197662001004875116164210279298344384430467508
of3720662001004670
138056620010042
episode3862662001004289109141187235277
(72.64154662001002365107125168
%).4332662001006687102
The4449662001004188130
most45946620010069115148176
common4785662001003782151220266312
symptoms853674001003373143190218263332365
were12366740010061102130171
vaginal1425674001004081127147192232252
itching169567400100204783129148194241
and1954674001004086133
cottage2106674001003782109138179226267
cheese-like2392674001003783125167200242270290309348389
vaginal2799674001004080127146192232252
discharge,306967400100476699136182222249295337353
affecting344167400100406491133171200219265312
89.73771674001004385100142
%39236740010066
and4007674001004086133
71.7415967400100428296138
%43076740010066
of4391674001004670
women44796740010062107176218265
with4762674001006181108154
VVC,4935674001004696143161
respectively.853685001002768101148190228257276316357377416429
Stress129768500100416794135168200
(57.21512685001002364104113158
%)1680685001006687
was17816850010061101134
the1930685001002773114
main20596850010069109128174
self-reported224868500100337494119143171212259305333362403451
factor2713685001002565102131176203
associated2931685001004072105150188207247274314362
with3308685001006180108153
the3476685001002873115
VVC,3606685001004696142161
followed378168500100257090109155215256304
by4099685001004886
antibiotic4200685001004085112131178198243270289326
therapy4541685001002873115142182229268
(49.74823685001002464105119161
%).4994685001006687102
Only8536970010057104123162
51.0103069700100438194137
%11776970010066
of1258697001004569
women13426970010061106176217264
with1620697001006181108154
VVC1789697001004696142
sought1946697001003379125171217244
a22046970010040
doctor’s2259697001004793130160204232250280
help,2554697001004688108155171
35.2273969700100438399144
%28936970010066
of2973697001004670
women30586970010061106175217263
reported3336697001002768116162189219260307
about3658697001004087133179206
self-treatment.387969700100337594119143171197239279305374416462489507
The4400697001004288130
management45456970010069109155194241283352394440466
of5026697001004670
VVC853709001004696143
included1013709001001965102122167214256304
usage1333709001004679120166208
of1557709001004670
medicines16447090010069111159178215234280322355
and2016709001004086133
nonmedicinal2165709001004692139208250297317354373419459478
interventions.266070900100196592133160203244290317336382428461478
Oral3155709001005785125145
antifungals3316709001004086113132157203249296336355388
and3720709001004086134
vaginal3870709001004080127146192232251
medicines41387090010069111159178215235280322355
prevailed4510709001004774116155196215234276324
(86.24850709001002465108126170
%50317090010066
and853720001004086133
80.71005720001004285102144
%11607200010065
of1244720001004570
woman13327200010061106176216262
with1612720001006281109155
VVC1785720001004696143
used1947720001004578120168
them,2133720001002873115185202
respectively).2354720001002768101148191229258277317358378418440455
The2827720001004289131
management29767200010069109155195242284353395441468
of3463720001004570
VVC3551720001004696143
was37137200010061101134
associated3865720001004073105151189208248275316363
with4247720001006181108154
inappropriate4420720001001965105152199227272320347367407434475
interventions,491372000100196592133161853732001004081127154173218265297314
such1182732001003378116161
as1358732001004073
the1446732001002773115
treatment157673200100275495135162231273319346
of1937732001004670
an2022732001004086
asymptomatic2123732001004072112182229256301371411438457494
sexual2632732001003374114159199219
partner2866732001004787114144190232259
(22.83140732001002465107124168
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vaginal3436732001003980126145191231250
douching3701732001004793139176222241287333
(11.0404973200100246296110152
%),4212732001006586102
taking4329732001002768106127173219
oral4563732001004673113133
antifungals4711732001004086112131156202248295334354386
https://doi853465007936567911614115217819710474650080387591
https://8534650079365679116141152178197
.org/10.36290/csf.2025.0221138465007911476710312812654650080346680116150184218253275303331351364400434467502515550583617
PLNÁ5107440018990171278381
VERZE92474400189101186283376463
ČLÁNKU➜14197440018991173279386486594204874500224139
https://doi.org/10.36290/csf.2025.02222207450017880123172253307330385424263574500181851662002831745001782610414722527831047450018177145174254328401475552600659719763788868941101310881116119212631338
POUZE5107640014564151233301364
PRO9077640014564132219
PŘEDPLATITELE11607640014564131195279347407487543577642706766829
ČASOPISU20237640014570149214301370401464544
ČESKÁ26017640014569132196264347
A29817640014574
SLOVENSKÁ30897640014559119203273337420483552634
FARMACIE37577640014558130198300378449481544