| E1 PŮVODNÍ PRÁCE Anticonvulsant biotargets of digoxin: in silico study and in vivo verification https://doi https:// .org/10.36290/csf.2025.021 Anticonvulsant biotargets of digoxin: in silico study and in vivo verification Vadym Tsyvunin1, Hanna Severina2, Sergii Shtrygol’1, Victoriya Georgiyants2, Diana Shtrygol’3 1Department of Pharmacology and Clinical Pharmacy, National University of Pharmacy, Ukraine 2Department of Pharmaceutical Chemistry, National University of Pharmacy, Ukraine 3Department of Neurology, Psychiatry, Narcology and Medical Psychology, School of Medicine, V. N. Karazin Kharkiv National University, Ukraine One of the promising ways to control multidrug-resistant epilepsy may be to use, in addition to traditional antiepileptic drugs (AEDs), medicines from other pharmacological groups – the so-called „non-antiepileptic” drugs. Among such drugs, the cardiac glycoside digoxin deserves special attention. It was established that sub-cardiotonic doses of digoxin exhibit both their own anticonvulsant effect and have been shown to enhance the anticonvulsant potential of classical AEDs. However, the mechanisms of this action and the probable cerebral biotargets with which these properties of digoxin may be associated, remain completely unknown. Molecular docking of digoxin to the following cerebral biotargets was performed: GABAAR, GlyR, mGluR5, AMPAR, hBCATc, mGlu8R, NMDA-GluN1, KCNQ2, COX-1 and COX-2. To confirm the in silico results in vivo pharmacological studies under conditions of acute bicuculline-induced seizures and pentylenetetrazole kindling in mice have been carried out. It was established PLNÁ VERZE ČLÁNKU➜ https://doi.org/10.36290/csf.2025.021 POUZE PRO PŘEDPLATITELE ČASOPISU ČESKÁ A SLOVENSKÁ FARMACIE E10 | PŮVODNÍ PRÁCE The management of vulvovaginal candidiasis: the results of survey in Lviv, Ukraine The management of vulvovaginal candidiasis: the results of survey in Lviv, Ukraine Oksana Horodnycha1, Tetiana Ryvak1*, Oksana Nepyivoda2 1Department of HealthCare Management, Pharmacotherapy and Clinical Pharmacy, Faculty of Pharmacy, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine 2Emergency Hospital of Lviv, Ukraine Vulvovaginal candidiasis (VVC) is a serious clinical and social issue. The questionnaire-based study was performed to assess the management of VVC in Lviv, Ukraine. Totally 408 women were enrolled in the survey. The lifetime prevalence of VVC was high (72.6 %). 35.8 % of women had VVC during the last year with the predominance of 1 episode (72.6 %). The most common symptoms were vaginal itching and cottage cheese-like vaginal discharge, affecting 89.7 % and 71.7 % of women with VVC, respectively. Stress (57.2 %) was the main self-reported factor associated with the VVC, followed by antibiotic therapy (49.7 %). Only 51.0 % of women with VVC sought a doctor’s help, 35.2 % of women reported about self-treatment. The management of VVC included usage of medicines and nonmedicinal interventions. Oral antifungals and vaginal medicines prevailed (86.2 % and 80.7 % of woman with VVC used them, respectively). The management of VVC was associated with inappropriate interventions, such as the treatment of an asymptomatic sexual partner (22.8 %), vaginal douching (11.0 %), taking oral antifungals https://doi https:// .org/10.36290/csf.2025.022 PLNÁ VERZE ČLÁNKU➜ https://doi.org/10.36290/csf.2025.022 POUZE PRO PŘEDPLATITELE ČASOPISU ČESKÁ A SLOVENSKÁ FARMACIE
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