523
|520775008316
E152587500833468
/2900745009227
Čes.296674500924380109123
slov.31067450092294586120130
Farm.32537450092366790154167
2024;73(4):XXX-XXX343774500923875110144157192229248284302314357401444465504548591
/4067745009227
ČESKÁ415074500924481119158207
A4376745009245
SLOVENSKÁ443974500923671122162201251287326375
FARMACIE483374500923578118180227271288325
www.csfarmacie.cz794745009256114172183217247268304327391425460476513526561594
ORIGINAL45777500844890110158179227273308
ARTICLE49017500844384122142185220257
Rising228184008235497589125163
consumption24598400823167104129165222260281295332370
of28448400823654
anticoagulants2913840082326889104135170202240277291322359380407
in33358400821451
Central34018400823971108129150182196
and36128400823268106
Eastern3733840082326490112145165202
European3950840082326888124163197228265
countries42308400823066103140160181196230256
in45018400821451
the4567840082215892
period4674840082377292107144182
2007–201948718400823467102133165195228259288
https://doi.org/10.36290/csf.2024.0364101940082375781119145157183202430094008339779443949400821249701071324524940083356882119155189224261283312340361374412447480514529565599634
Rising79413600237116172256311423535
consumption1366136002378519630839250466878285491010201132
of253613600237111178
anticoagulants2752136002371032152863424265366397508629171020113212031288
in7941590023755167
Central99915900237113211324395472572627
and166315900237103215330
Eastern203015900237104207292363464540652
European271915900237104216291402516617721833
countries7941810023785195307420490567621721806
in16371810023755168
the18421810023772186287
period216618100237115217293346457571
2007–2019277518100237107213323427511612718818917
Kateřina7942140011758108142192228254309359
Malá-Ládová1,11722140011780130156206237287338394448497546171221400683017412140011724
Helena17842140011765115142192248298
Šťastná2101214001175184134175210266315
Koblihová1,2,243621400117571101661932182743283774262856214006830447629332140011724
Eva29762140011751100149
Zimčíková1,3144214001175479161203230282336384434357221400683036012140011724
Anna36442140011762117172222
Oleárová3,3885214001176794144194230285333383426721400683042982140011724
Ria4341214001175683133
Benko4,44932140011756106162213267476121400683047932140011724
Maria7942260011780130166191241
Matuz4,10542260011780130164220264131922700683013512260011724
Reka13942260011756106158208
Viola4,1621226001176086140167217183722700683018692260011724
Katarina19122260011758108142193229254309359
Gvozdanovic5,22902260011764113166210267317372427475501544283422700683028662260011724
Pero29092260011755103140194
Draganic6,31222260011766102151206257312338380350222700683035342260011724
Irina357722600117276389144194
Iaru7,3790226001172777113167395522700683039822260011724
Josef4025226001173994134184217
Malý1426122600117801301562054465227006830
1Department7942400066288202400011463110164209239273351398450480
of1320240001145178
Social1418240001144798141162207228
and1666240001144697150
Clinical183624000114557697149170212257279
Pharmacy,21352400011450101145176254299341387402
Pharmaceutical25572400011450100145175254299340386438468490531577599
Faculty3176240001144587129180201232278
in3474240001142274
Hradec3568240001146192137190237280
Králové,3868240001145182127149201245290309
Charles41972400011454105150180202249286
University,45032400011461112134179224255293314345391406
Czech794252001145596143186237
Republic1051252001145198151203256278299341
2Department7942660066288222650011463110164209239273351398450480
of1322265001145178
Clinical142026500114557697149170212257279
Pharmacy,17192650011450101146176254299341387402
Hospital21412650011461113149202224255300322
Rudolfa24832650011451102155206229256302
a28052650011445
Stefanie,2870265001144675121149195246268314333
Benešov,3223265001145198150197234285329344
Czech3587265001145496143185237
Republic3844265001145097151202255278299341
3Department7942790066288222780011463110164209239273351398450480
of1322278001145178
Clinical142027800114557697149170212257279
Pharmacology,17192780011450101146176254299341391413465518562577
University23162780011461112133178224255292314344391
Hospital27272780011461113150202224255300322
Bratislava3069278001145182127157178215236281324369
–34582780011447
Hospital35252780011462114150203225255301323
Ružinov,38682780011450102142163215266310325
Bratislava,4213278001145181126157178214236281324369389
Slovakia4621278001144768120164209253276320
4Institute794291006628823291001142274111142163194245276322
of1165291001145279
Clinical126429100114547597148170211257278
Pharmacy,15622910011450101146176254299341387402
University19842910011461112134179224255293314344391
of2395291001145279
Szeged,2494291001144686132185232286305
Hungary28192910011461113165217262292339
5Department7943040066288223040011463110164209239273351398450480
of1322304001145178
Pharmacoepidemiology,14203040011450101146176255300341391439492514567614692714765787839892936951
Teaching2391304001144787132174226247298351
Institute2762304001142274110142163194245276322
of3104304001145279
Public32033040011450100153175197238
Health34613040011462109154175206258
„Dr.3739304001143397127142
Andrija39013040011458110163193215236281
Štampar“,4202304001144675121199252297327362375
Zagreb,4597304001145298151181227281299
Croatia794317001145584135181211232277
6Agency7943300066288223290011458109156208250296
for1138329001142879109
Medicinal12673290011476124177198240261313358379
Products1666329001145080131184235277310348
and2034329001144597150
Medical22043290011476123176198240285307
Devices,25313290011462110154176218264300320
Zagreb,2871329001145298150180227280298
Croatia3189329001145584135181211232277
7Department7943430066288223420011463110164209239273351398450480
of1322342001145178
Pharmacology,14203420011450101146176255299341391414465518563577
Physiology20173420011450101143180201253275326379424
and2461342001144597150
Pathophysiology,2631342001145094124176227280333375412433484507558611656670
Faculty3321342001144688129180202233279
of3620342001145279
Pharmacy,37193420011450101145176254299341387402
Iuliu414134200114227395116167
Hatieganu43283420011462107137158205258303355406
University47543420011461112133178224255292314344391
of794355001145279
Medicine8933550011475123176198239261312359
and1272355001144597150
Pharmacy,14423550011450101146176254299341387402
Cluj-Napoca,1864355001145475127149178241287340392434480499
Romania23833550011451102181225277299343
Introduction794398001052373103134184235284324357379428478
and1291398001054493144
Aim:1454398001055577151171
Due16443990010357106149
to1813399001032875
the1907399001032977121
growing2047399001034877124187208257305
incidence2372399001032068107128177221269309351
of2743399001034773
thromboembolic2835399001032876105152225274323367439489537559579618
disease3473399001034869103147189223267
and3760399001034189138
atrial391839900103417098119161182
fibrillation,411939900103254998127148169189231260280328377396
increasing4534399001032068107136179221256276324373
trends4926399001032957101149199233
in794411001032068
anticoagulants881411001034189117138177224267315363384426474502538
consumption1437411001033986134168216288337366387435483
can1939411001033881129
be2086411001034993
expected.2198411001034384134179218250293342361
The2578411001034291135
aim2732411001034162134
of2884411001034773
this297541100103297797132
study3125411001033464112161203
was33464110010363105140
to3504411001032976
analyse3598411001034190131152194229273
the3889411001032876120
consumption4028411001033885134168215287337366386434483
of4529411001034773
anticoagulants4621411001034189117138177224267315363384426474502538
in794423001032068
the882423001032876120
Czech1022423001035089132172220
Republic,1262423001034690140188238259280319338
Croatia,1620423001034977125167196217258277
Hungary,19174230010356104152201243272315330
Romania,2267423001034694166208256277319338
and2625423001034189138
Slovakia2783423001034263111152195235257299
between3102423001034993123189232276325
20073446423001034488134177
and3643423001034189138
2019.3801423001034488129168184
Methods:7944340010571116148198247298335356
A11714350010352
retrospective1245435001032871101130177212261305345376397439482
analysis1749435001034189131152193228248283
of2053435001034773
anticoagulants2148435001034189118138177224267315363384426474502538
comprising2708435001033885157207236257291311359408
B01AA,3138435001034691132180235256
B01AB,3415435001034792133181227246
B01AE,3683435001034691132180223242
B01AF3946435001034792133181223
and4190435001034290139
B01AX4351435001034691132180232
was46044350010363105140
performed4765435001034994123151199228300345394
using794447001034782102150199
ATC/DDD1015447001035290139170229287345
methodology.13824470010371115144192240290338360408457499514
The1917447001034392136
analysis2075447001034189131152193228249283
was23804470010363105139
initiated254144700103206889118138180209252302
in2864447001032068
the2954447001032877121
year3096447001034184126154
before3272447001034993119167196240
the3533447001032977121
launch3676447001032062109157197245
of3942447001034773
the4037447001032876120
first417944700103254877112142
non-vitamin4343447001034795144172214235265307379400448
K48134470010346
oral4881447001034776118139
anticoagulant504244700103418979445800103284988135177226274295337385413
(NOAC).1231458001032581141192240267283
The1538458001034392136
consumption1698458001033885134168215287337366386434483
of2205458001034773
each2302458001034384124172
drug2498458001034877125174
was26964580010363105139
assessed2859458001034276110154189223267317
based3200458001034991126170220
on3444458001034795
annual3563458001034190138185227248
data3835458001034890119162
and4021458001034189138
was41834580010363106140
expressed4347458001034384134163206241275319369
as4740458001034276
DDD48404580010357115173
per5037458001034993122
1,000794470001034458103149196
population1009470001034998147196217259287308356404
per1433470001034993122
day1575470001034890130
(DDD/TID).1725470001032481140198226273294352375392
Results:794482001054892127175197227263283
The1092482001034289132
overall1240482001034686127155196216236
rates149248200103276896137171
of1678482001034671
anticoagulant1765482001034087115134172217259306352372413459487
consumption2268482001033783130163209279327355374421468
increased2752482001031966104132174214248290339
in3106482001032067
all318848200103416180
countries.3284482001033883130177204232252294328346
Specifically,3646482001034189132170190215237275316336356396410
doubled4072482001034793140188209251300
in4387482001032067
the4469482001032875117
Czech4602482001034986129167214
Republic,4832482001034587136182230251271308326
Croatia,794494001035078125168197217259278
and1089494001034190139
Slovakia,1245494001034263111153195236258300318
more15814940010371119148192
than1790494001032876118167
tripled197449400103285778127149193242
in2234494001032068
Hungary23194940010356104152201243272316
and2652494001034189139
more28084940010371120149192
than3017494001032977119167
quadrupled3201494001034896138187216264314335379429
in3647494001032068
Romania.3733494001034694166208256277319338
Parenteral4088494001034687116159207236279308350371
anticoagulant4477494001034189118138177224267315363384426474503
consumption4997494001033885134794506001033481153203232252300349
remained1161506001032871144186206254298348
stable1527506001033464107156177221
or1766506001034776
decreased,1860506001034892132161204246281325375393
while22715060010363112132153197
the2486506001032876120
proportion2624506001034978126175224253285305353402
of3044506001034772
oral3134506001034776119140
anticoagulants3292506001034189117138177224267315363384426474502538
increased3848506001032068107136179221256300350
from4216506001032554102174
an4408506001034189
average4515506001034282125154196245289
of4822506001034773
61.41%491350600103448398143182245
in794518001032068
2009886518001034387133178
to1088518001032875
66.95%1187518001034489108151195262
in1472518001032068
2019.1564518001034488129168184
The1772518001034291135
use1931518001034782126
of2080518001034773
vitamin217651800103416392135207227275
K24755180010346
antagonists2545518001034189118160209257306326360390426
declined,2994518001034993132153174222266316334
with3352518001036384113161
the3537518001032876120
highest3681518001034768116164208243273
rate397751800103287199142
in4143518001032068
the4235518001032876120
Czech4378518001035089133173221
Republic4622518001034690140188238259280319
(11.164964518001032565101116155195
DDD/TID7945300010356114171199245266324
in1134530001032067
2019).1218530001034387127166189205
NOAC14405300010355115166213
consumption1670530001033884132165212283332361381428476
showed2163530001033381128191233282
substantial2462530001033380129163192234282310330371392
growth:2870530001034876123185216264281
from3168530001032454100172
0.0023356530001034462106152193
to3566530001032874
8.333657530001034362109151
DDD/TID38245300010357114171199245266324
in4164530001032067
the4248530001032875119
Czech4383530001034988131170218
Republic,4617530001034689138186235256276314333
0.0014966530001034462106151192
to794542001032875
6.73890542001034463107150
in1061542001032068
Croatia,1149542001035078126168197217259278
0.0091447542001034462107154199
to1666542001032875
8.311762542001034463110150
in1932542001032069
Hungary,20215420010356104152201243271315330
0.00052371542001034462107153200244
to2635542001032875
5.402731542001034461106152
in2903542001032068
Romania,2992542001034694166208256277319338
and3350542001034189139
0.033509542001034462107150
to3680542001032875
10.773776542001034484102146191
in3987542001032068
Slovakia.4076542001034263111152194235257299318
By4414542001034788
2019,4523542001034487128168184
rivaroxaban472754200103284991134162210250292341384432
was7945540010363105140
the953554001032977121
most10945540010371119153183
commonly1297554001033885158230278326347389
used1705554001034882126176
NOAC19015540010356116167216
in2137554001032068
all222455400103426383
countries,2327554001033885133182210239260304338357
apart2704554001034191133162193
from2917554001032555102175
Romania.3111554001034694167209257278319338
Conclusion:794566001055098148188211260297320369419439
The1252566001034392136
study1407566001033363111160202
showed1628566001033482130193236286
an1933566001034190
overall2042566001034788131160202223243
increase2304566001032169108137180222256300
in2623566001032068
the2710566001032977121
anticoagulant2850566001034189118138177224267315363384426474503
consumption.3371566001033986134168216288337366387435483502
However,38925660010356104168211252295324339
specific4250566001033483127167188214237276
characteristics4545566001033886128157199238270313342363397427447486522
of5086566001034773
individual794578001032068117137179200249296338358
countries1169578001033885133180209237258301336
need1521578001034891135185
to1723578001032875
be1814578001034993
further1924578001032573101133180224253
analysed2193578001034189131152193227271320
to2530578001032875
better2622578001034892121152195224
understand2862578001034795144188216251281323371420
the3299578001032876119
different343557800103486994123166195238286315
factors3766578001032568107137184213248
influencing403157800103206793116163207255294314362410
utilization445857800103477696117137174217246266314362
patterns.4837578001034890119149192221269303322
Key794593001055093135
words:9475930010564111142192228248
drug1213593001034876123171
utilization140359300103477595115134171214241261308356
analysis,1777593001034189130150190224244277295
Europe,2090593001034288116163211255272
oral2380593001034775117137
anticoagulation,2535593001034189116136174220262310357377418446465512560578
parenteral3131593001034990118161208236278306348368
anticoagulation.3517593001034188116136174220262310357377418445465512560578
Rostoucí7946150012963125172212273336383415
spotřeba12316150012946110172212256312376434
antikoagulancií16876150012956119159190251311368430492523581643691722753
v24636150012956
zemích25426150012950106197228275339
střední2903615001294686130186251313345
a32706150012956
východní33496150012956116161225286350413444
Evropy38156150012957113156217281336
v41736150012957
letech4252615001293087127184232295
2007–201945696150012959118179237285341400456511
Úvod7946310010557101148198
a10096310010543
cíl:106863100105396184104
S11886310010342
rostoucí1247631001032875108137183231269289
incidencí1552631001032068106126174217265303323
tromboembolických1892631001032856102174223270314385434482502522560600643680727
onemocnění2636631001034795138209257296343386433453
a31066310010341
fibrilace316463100103254796124144164205243285
síní3466631001033453101120
lze3603631001032057100
předpokládat3719631001034977120169217265305327368416457485
rostoucí4221631001032875108137183231269289
trend452663100103295799147195
ve4738631001034183
spotřebě4838631001033482130158186228277320
antikoagulancií.794643001034187114133172216257304350369409455493512531548
Cílem135664300103496889131201
práce1571643001034875116153194
bylo1780643001034886106152
analyzovat1947643001034087127146185223269308349376
spotřeby2337643001033381127155181223271309
antikoagulancií2661643001034087113132171216257304349369409455493511530
v32066430010340
České3261643001034989122161202
republice3477643001032870117164211231250287328
(ČR),3820643001032369113136151
Chorvatsku,3986643001034994140168211251278312351397414
Maďarsku,44156430010367108156196223256295342359
Rumunsku4788643001034591161207253286325371
a7946550010341
na853655001034889
Slovensku960655001034262109150192239273313360
v13386550010341
letech139765500103216492134174221
2007−2019.1636655001034487132173220260303343382397
PharmDr.79469000823471102122179224245254
Kateřina10636900082346788121141156192224
Malá-Ládová,130169000825485100131153185217255292323355367
Ph.D.16836900082357183129140
Department79470100824479117149169193249283320341
of115070100823655
Social122070100823169100115146160
and139570100823168106
Clinical15167010082395468105119150182197
Pharmacy,172870100823470101122179210241273283
Pharmaceutical202670100823470101122179210241274310332347378409424
Faculty24657010082326091128143164197
in267770100821451
Hradec27437010082436395133167199
Králové,29577010082345587102139170203214
Charles318670100823976107128143177202
University34037010082438094126159179206220242274
ladovaka@faf.cuni.cz7947110082154684121151183213245295314346365376406443480494507538567
Cit.3996690008239547588
zkr:4099690008228577992
Čes.42066900082397298110
slov.43316900082264178108118
Farm.44646900082316080137150
2024;73(4):XXX-XXX46296900082336698129140172205222254271282320359398417452491530
Článek43027010082395485122155185
přijat4502701008237587387118139
redakcí:46567010082215492123152183197208
??.48797010082265261
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