602
|558421009719
22156432100974182120
/29368040010732
Čes.3013804001075193127144
slov.3177804001073352100140152
Farm.3349804001074278105179195
2024;73(4):216-2213564804001074487128168183224267290331353367412451490520559602642
/42518040010732
ČESKÁ4348804001075195139184243
A46128040010753
SLOVENSKÁ4686804001074283142189234293335381439
FARMACIE5146804001074292139211266317337381
www.csfarmacie.cz4258040010765133201214254289314356382457497538556600615655694
AKTUÁLNÍ44642000985199146202253295351375
FARMAKOTERAPIE48572000984190138207261309366410454502557603626670
Farmakoterapie3126320095377094160197231274298336360398442459499
chronického36423200953679103145188205241275314357401
srdečního4060320095305497136173216233278321
selhání4399320095296987129166209226
–464232009540
minimum47003200956582125142207250316
pro50333200954469111
farmaceuty5162320095205882148185222260302328366
musí4254260010774120152170
znát612426001073785124151
a7804260010741
dodržovat839426001074996145171208254294334361
úhradové1217426001074895121161210257297339
podmínky.1574426001074998147220237284321363374
Tato1966426001074276102148
omezení21324260010748121164200243290307
se2457426001073477
však2552426001074073114151
týkají2721426001072869107149167184
pouze425440001075098145181223
hrazení668440001074873114151193240257
z9454400010736
veřejného1001440001074083108150168215258306353
zdravotního1374440001073683109149188235261309326375423
pojištění,1816440001075098117134166194235282300314
nikoli2150440001074866103149168185
možnosti23554400010774121156204251284312330
léčiva2704440001072063103120160201
předepsat425454001075076117167210258291332358
jako80545400107195996142
takové.969454001072868106152191234248
V12384540010746
situacích,130645400107345178125165205222262309323
kdy1651454001073886125
by1798454001075088
byla1908454001075088107147
určitá2077454001074773111128155196
léčba2295454001071962102151191
indikována,2508454001071966114132169215255295343382397
ale425468001074159102
není548468001074992139157
hrazena,726468001074874114151193240280295
lze104246800107195597
pacientovi1160468001075090130148191238264310349367
navrhnout1549468001074888127153201248295343370
předpis1940468001075076118167216234266
optimální2227468001074897124142214254272319336
léčby2585468001071962102150189
dle2795468001074967110
guidelines425482001074996113162205223241288331364
za807482001073677
úhradu902482001074895120161210256
nemocným.1176482001074892164212252300337411426
Závěr4255070013965128189249296
Srdeční565524001074268116160201249268
selhání85052400107347897145186234252
je1120524001071963
chronickým1201524001074088114161210228268306349424
závažným1642524001073779119160197246284359
onemocněním,2019524001074896140214263304352396444462536552
nicméně2588524001074867107181225273317
recentní425538001072668108150197223271288
pokroky729538001074997135162208246288
v10325380010741
kardiovaskulární1088538001073879105152170217256297329366413432471497545562
farmakoterapii166653800107236590163203240286313355380421469488506
rozšiřují2188538001072672106141158184231249267
naše2471538001074787120163
terapeutické26495380010728699513618422842555200107477492131168209
možnosti6505520010772119153201248280308326
a9915520010740
především1047552001074874115164207246279296368
zlepšují143055200107365497145177223241259
prognózu1704552001074975120169215262297344
a20635520010740
kvalitu2118552001073880120138156183229
života236355200107355493139166206
pacientů.2584552001074989128146188235261307321
V30474260010746
posledních3113426001075099132151195245293312352400
letech353342600107196391133174222
jsme3775426001072052126170
svědky3965426001073476119168206249
rozvoje4234426001072774109153201220264
farmakoterapie451842600107236592166207245292319362388430480499543
chronického5081426001074088114161210228269306349398446
srdečního3047440001073358105148188235253302349
selhání.341244000107337694141181228245260
Při368844000107456988
inhibici3791440001071966112130179197236254
renin-angiotenzin-aldosteronového4061440001072668115133179207246293341359406433474521557576622650689707755803835863905930976102410711110115312001247
systému532444000107337310613417530474540010773120
je3183454001071963
u32624540010747
většiny3325454001074183110145163210248
pacientů3589454001074990130149192239266313
v39184540010741
současnosti3975454001073381128168209242289337370398417
doporučována4408454001074996146194221269309354394435483523
léčba4947454001071962103152193
kombinací5156454001073884158207225273313353371
sakubitril/valsartan.3047468001073476114162212232260287306325357399440459492534561592633682698
Kromě3772468001074573120195239
již403746800107203875
zavedených4139468001073678118162212256305344383432
tříd459746800107285574123
léčiv4747468001071963105123164
máme49384680010774115189233
nejnověji5198468001074893111160208249292311330
v30474820010741
této3116482001072872100148
indikaci3292482001071968119138177220262281
k36014820010738
dispozici3667482001075069103153203240260301321
glifloziny401548200107506988113136186222242291331
s43734820010734
jasným443548200107196195144184260
ovlivněním4722482001074991111130172223268317336411
morbidity51614820010775125152204224274294323366
a30474960010742
mortality31164960010775125153184227247266295338
pacientů3482496001075093135154199249276325
se3835496001073479
srdečním3941496001073562111156198248267342
selháním431149600107347999148190239258334
napříč4672496001074991142169189230
celým4929496001074185105146222
spektrem5179496001073484130170201229273348
hodnot3047510001074998149198247275
ejekční3349510001074464108147187236255
frakce,363151000107245294133173216231
tedy3889510001072872122163
s40795100010734
prokázaným4140510001075178126165209246289338378453
účinkem4620510001074990109157196240315
jak496251000107196099
u50885100010748
srdečního5163510001073461110155197245264315364
selhání304752400107347897145185234252
se3320524001073377
sníženou,3418524001073481100136179227276324340
tak3778524001072869107
se3906524001073378
zachovanou4004524001073779119167216256298346394442
systolickou4467524001073475108137184204222262300348396
funkcí.4883524001072473121159198217233
Znalost5136524001074996137156204238267
aktuální54235240010741793047538001072876116135183202
strategie326653800107346389131158201251269313
léčby3597538001071963104153192
různých3807538001072675111160199238286
typů4111538001072770121169
srdečního4297538001073460108152193241260310358
selhání467253800107347897145186234252
je4942538001071963
důležitá5022538001074996115159196215243285
nejen5324538001074893111155203
pro3047552001075077124
předepisující3190552001075077120170214263283315362381400440458
lékaře,3668552001071963101144170213227
ale3915552001074160104
také4038552001072870108151
pro4208552001075077124
farmaceuty.435255200107236592166207247290338366408420
LITERATURA426575001234978134189250318368438498567
1.42559200853648
Seferović4905920083326887121142180212227259
PM,76659200833588102
Vardas8845920083366788126159185
P,108659200833539
Jankowska11425920083245694124162213240270303
EA,14625920083327589
et156759200833457
al.16405920083324760
National17175920083447798114152190222238
Heart197159200834479111132157
Failure2145592008332617692129150184
Societies234659200833271103118153175191225252
of261559200833756
the26885920083216095
ESC279959200833366107
member42560200835792150190225246
countries.69160200833168106144166187203238265278
The98960200833372107
Heart111660200834479111132157
Failure1292602008333627793130151185
Association14976020083416996134166182214235251289327
Atlas:18446020083416278110136149
heart201360200833772104125150
failure2183602008318516782119140175
epidemiology23776020083347489128163221236274290328367400
and279660200833270109
management42561200835790128160199234292327365387
statistics8276120083264982104119145168184215243
2019.108561200833569101131142
Eur12426120083336990
J1348612008324
Heart138761200834479111132157
Fail.1559612008333627792105
2021;26.168061200833468101132140175209222
2.42562200853652
Špinarová4926220083327187125157178215247280
M,78762200835568
Špinarová8716220083327186124157178215247280
L,116662200833145
Špinar12266220083337287125157178
J.142062200832436
Kardiol14726220083356889127143181197
Rev168462200833570102
Int18026220083155374
Med.189162200835590129143
2015,17(2):131-135.204962200833468100130141172202218252270282312342373391422452485497
3.42563200853752
Heidenreich4986320083458197136172211233268284316355
PA,8756320083357488
Bozkurt98563200833575104135174196222
B,122863200833649
Aguilar129863200834281120135151184206
D,152563200834658
et160463200833457
al.16836320083324861
2022176663200833469103139
AHA/ACC/HFSA192663200834287130158196236275303350383416458
Guideline24056320083458499139175191207245281
for27086320083185779
the28086320083226197
Management42564200835487125157196231289324362384
of82564200833756
Heart89764200834479111132157
Failure:1070642008332627792129151185197
Executive12836420083336599132170192207240274
Summary:157364200833370128186218239273287
A1876642008341
Report193264200833671110149170195
of214364200833757
the22156420083226095
American232664200834199134155171203236274
College26166420083407793108142182217
of284964200833756
Cardiology/American4256520083407394132147185201239279311334372429465486501533566604
Heart104365200834479111132157
Association12146520083416995134166181213235250288327
Joint15556520083246278116137
Committee170665200834077135193208231255289324
on204465200833776
Clinical21346520083405570108123155187203
Practice23516520083355689121145160192226
Guidelines.25916520083438297136170186201239274301314
Circulation.4256620083405576107145160193214230268306319
202276066200833468101136
May91166200835487118
3;145(18):e876-e894.10446620083344676107139157189220238250284319352384408444479513549562
4.42567200853651
McDonagh49767200835587133171210242281319
TA,8376720083327084
Metra94167200835590112134167
M,112867200835568
Adamo121767200834179111169208
M,144567200835568
et153367200833457
al.16106720083324760
2021169167200833468101133
ESC184467200833367107
Guidelines19726720083438297136171186201239274301
for22946720083185677
the23926720083216095
diagnosis25076720083385386125163201228243269
and279667200833270109
treatment4256820083224377109131189224262284
of72468200833756
acute79668200833264101124158
and96968200833270109
chronic10936820083327091128166181213
heart132268200833772104125150
failure.1487682008319526782120141175187
Eur16896820083337091
Heart179568200834479111132157
J.196768200832437
2021201968200833468101133
Sep216768200833368107
21;42(36):3599-3726.22896820083346674109141159192227245257292325357392416448481515548562
5.42569200853650
McDonagh49069200835487132171210242281319
TA,8236920083337084
Metra92169200835590112134167
M,110269200835468
Adamo118469200834179112170208
M,140669200835568
et148969200833356
al.15596920083324760
2023163469200833468101135
Focused178469200833269102140166201241
Update203969200834483122155176210
of226369200833857
the23346920083226095
2021244469200833468101132
ESC259069200833367107
Guidelines271269200834482971361714257020083153068103130
for5747020083195678
the6727020083216095
diagnosis7877020083385385124162200227242268
and107570200833169108
treatment12037020083224378109131189224262284
of150770200833756
acute158370200833264102125158
and176170200833270109
chronic18907020083316990127166181213
heart212370200833772104125150
failure:2293702008318526782119141175187
Developed250070200834581113147163201241276316
by283570200833970
the4257120083226095
task5397120083225481111
force6697120083185677109142
for8307120083195678
the9277120083226095
diagnosis10417120083385385124162200227242268
and132871200833270109
treatment14567120083224377109131189224262284
of175971200833756
acute183571200833163101124158
and201271200833169109
chronic21407120083316990127166181213
heart237271200833772104125150
failure2541712008318526782120141175
of273571200833756
the28117120083215994
European4257220083336990128167203235273
Society71572200833371104119153176209
of94272200833756
Cardiology10167220083407394132147185201239279311
(ESC)13447220083195285126146
With15087220083577396134
the16607220083215994
special177272200832665101133148180196
contribution198572200833168107128150165204243265281318357
of235972200833857
the24347220083215994
Heart254672200834479111132157
Failure2720722008332627792130151185
Association4257320083416995134166181213235250288327
(HFA)7677320083196396134153
of93573200833857
the10077320083226095
ESC.111773200833367107121
Eur12537320083326990
J1358732008325
Heart139873200834479111132157
Fail.1570732008332627792105
2024169073200833569102133
Jan;26(1):5-17.18397320083245694106141175194225240252287309340369375
6.304759200853650
Marcondes-Braga310859200835486105135170208245279304324359379411449479
FG.35995920083327487
Pharmacological369759200833571102122179210241276291327366379410441455
Treatment41635920083334981112132189223259279
Sequencing445359200833367105141174211242256292330
for47945920083185474
Heart488059200834477108127151
Failure5042592008332607488124144176
with52295920083516586123
Reduced536359200833569107143304760200833164102
Ejection31616020083334680111134148184221
Fraction.33956020083325182113136150186223235
ABC364260200834176115
Heart377060200834478108128151
Fail3934602008332607487
Cardiomyop.40346020083407191128142178235264301339350
2022;2(1):31-5.43966020083356799132143177193223236246280310327360370
7.304761200853643
Maddox310461200835486123161198227
TM,33446120083328698
Januzzi34556120083245592128156186200
JL366861200832455
Jr,37366120083244452
Allen38016120083415569102139
LA,39536120083317386
et405261200833455
al.41206120083324657
202441906120083346798129
ACC433261200834179115
Expert446061200833364102136156179
Consensus465261200834076113138172208233269294
Decision495961200834579110124149162199236
Pathway52086120083356686123172203233
for54546120083185474
Treatment30476220083324779109129185218254273
of333062200833754
Heart339462200834376106125148
Failure3551622008332607386122141173
With37346220083567091127
Reduced387162200833467105140170202239
Ejection41206220083324578109131144180216
Fraction:43466220083325081111133146182218229
A4584622008341
Report463462200833568105142161184
of482862200833654
the48916220083225891
American499162200834196129149162192223259
College52596220083407589102135172205
of547462200833654
Cardiology30476320083407190127140176191227265295
Solution33526320083326983119140154190227
Set35886320083336687
Oversight368563200834678111130156169206242262
Committee.395763200834075131187201222244276310321
J4287632008324
Am432163200834197
Coll44286320083407589103
Cardiol.45416320083397090126140176190202
202447536320083346697127
Apr48906320083417898
16;83(15):1444-1488.49986320083346474108140157186215232242270299335370391420450484517529
8.304764200853650
McMurray311464200835485139176195216247277
JJV,3407642008324478290
Packer35136420083356596125158177
M.370664200835567
How379064200834481130
Should393664200833369106143157194
We414664200835890
Sequence425264200833266104140174210241273
the45416420083225992
Treatments46496420083334982112132189223259280306
for49716420083185575
Heart506264200834478108128151
Failure5229642008332617488124144177
and542264200833168106
a3047652008332
Reduced309565200833669108144174207245
Ejection33576520083324679110133147184221
Fraction?:35946520083335183113136150187224247257
A3868652008341
Redefinition392565200833669107141157174210224245259296333
of427465200833855
Evidence-Based43466520083336378115148185216248270306337362396434
Medicine.479765200835488126140170184221254265
Circulation.50796520083395373103139153184204218255292303
202153996520083346798129
Mar304766200835486105
2;143(9):875-877.31656620083344574103135151182199209243274306326361392426430
9.304767200853648
Solomon31086720083326984121178214252
SD,33726720083337686
McMurray347167200835485139175195215247276
JJV,3760672008324478290
Vaduganathan386367200833565103139176207244275295332363399
M,427567200835567
et435467200833455
al;44226720083324656
FINEARTS-HF44916720083324589121162197229261282327358
Committees486267200834076132189203224247279313338
and521367200833269106
Investigators.5332672008315518111414016117530476820083386989125145170183
Finerenone32406820083324682115135168204241278312
in356268200831451
Heart362368200834477108128151
Failure3784682008332607488124143176
with39706820083506586122
Mildly41026820083556982120134164
Reduced427668200833669107143174206244
or453068200833758
Preserved45986820083355487112145165198231269
Ejection48776820083334780111134147184221
Fraction.51086820083325182113135149186223234
N5353682008344
Engl540768200833369107121
J3047692008324
Med.308469200835488126138
202432346920083346799129
Oct337669200834778100
24;391(16):1475-1485.34896920083346575109140171185215245262272300330361392413442472506539550
10.30477020085366882
Kittleson3139702008335507194108141166203240
MM,3389702008355108120
Panjrath351970200833566102116135167187224
GS,37537020083447587
Amancherla385070200834197128164195232265285299330
K,419070200833548
et424870200833455
al.43137020083324657
202343807020083346798132
ACC452270200834178115
Expert464770200833263102136155179
Consensus483670200833975112137170207232267292
Decision513870200834679111124149162199236
Pathway53847020083356586122304771200835182111
on317071200833774
Management325571200835586122153191224281314351371
of363771200833856
Heart370471200834478108128151
Failure3866712008333617488124144177
With40547120083577293130
Preserved41957120083355487113146166199232270
Ejection44777120083324679110133147184221
Fraction:47097120083325182113136150186223234
A4954712008341
Report500671200833669107144165188
of520571200833755
the52717120083225992
American5375712008341971313047722008321356597134
College31967220083407690104137175209
of342172200833755
Cardiology34917220083407292128142179193230268299
Solution38057220083337084120142155192229
Set40507220083326687
Oversight415272200834780112132158171209245266
Committee.443372200834076133189203224247279313324
J4773722008324
Am481272200834198
Coll49267220083407590103
Cardiol.50457220083407191128142178193204
202352657220083346798132
May541272200835586115
9;81(18):1835-1878.30477320083344679110124154183200211239269301333353383412444476488
Léčba2699810012550102148207259
HFpEF2979810012569121178231283
SGLT225461450016168155220276347
inhibitor29201450016133108184217294328374447493
Pacienti14572320012354101147170222278312335
s14472440012340
retencí1509244001233384117168224270294
tekutin1484256001233484132189223246303
NYHA14092690012367122187250
II–IV168126900123244899124181
Titrovat15083250097405884110154192230256
Kličkové15023740088405775107141181216252
diuretikum14683830088415898122158182199233274335
Přidat24313250097436887132171197
Přidat33253250097436887132171197
Přidat42193250097436887132171197
Ženy315324400884076116150
(bez33182440088216299130
ohledu34642440088408097134175215
na319125200884076
hodnotu328225200884181122162202226266
EF)35642520088367192
Muži311726100885999130147
s3280261008829
EF332426100883671
<3411261008843
55–60347026100883775111148186
%3671261008858
Pacienti407523500883972105122158199223240
vhodní433023500883576116157197214
k4098244008834
terapii41482440088246084118160177194
ARNI,435824400884483131149164
kteří40412520088345894118136
jej41922520088185472
nemohou427925200884177138178219259299
užívat40692610088407188123158182
z4267261008831
důvodu431326100884182117156197237
ceny398027000883369109143
nebo413827000884177119159
intolerance43122700088175881121138175198233274306342
Ženy225923500884076116150
(bez24242350088216299130
ohledu25702350088408097134175215
na229724400884076
hodnotu238824400884181122162202226266
EF)26702440088367192
Muži222425200885999130147
s2387252008829
EF243125200883671
<2518252008843
55–60257725200883775111148186
%2778252008858
Pacienti240226100883972105122158199223240
s2286270008829
retencí23302700088246084120161193210
tekutin25562700088246094135159176216
MRA2451378009764108157
ARNI334137800974992145164
ARB424937800974992136
Obr.425590011466122160181
6.62459001145279
Doporučený748590010756102148194220266303340386422
postup118659001074591121147193238
léčby14405900107195794139175
pacientů163159001074591128146184231256301
s1948590010731
HFpEF;199659001075493136176214227
upraveno224059001074591117159197234281326
podle258259001074591137156194
(10)27925900107246198121