| E1 / Čes. slov. Farm. 2024;73(4):XXX-XXX / ČESKÁ A SLOVENSKÁ FARMACIE www.csfarmacie.cz ORIGINAL ARTICLE Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007–2019 https://doi.org/10.36290/csf.2024.036 Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007–2019 Kateřina Malá-Ládová1, Helena Šťastná Koblihová1,2, Eva Zimčíková1, Anna Oleárová3, Ria Benko4, Maria Matuz4, Reka Viola4, Katarina Gvozdanovic5, Pero Draganic6, Irina Iaru7, Josef Malý1 1Department of Social and Clinical Pharmacy, Pharmaceutical Faculty in Hradec Králové, Charles University, Czech Republic 2Department of Clinical Pharmacy, Hospital Rudolfa a Stefanie, Benešov, Czech Republic 3Department of Clinical Pharmacology, University Hospital Bratislava – Hospital Ružinov, Bratislava, Slovakia 4Institute of Clinical Pharmacy, University of Szeged, Hungary 5Department of Pharmacoepidemiology, Teaching Institute of Public Health „Dr. Andrija Štampar“, Zagreb, Croatia 6Agency for Medicinal Products and Medical Devices, Zagreb, Croatia 7Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Introduction and Aim: Due to the growing incidence of thromboembolic disease and atrial fibrillation, increasing trends in anticoagulants consumption can be expected. The aim of this study was to analyse the consumption of anticoagulants in the Czech Republic, Croatia, Hungary, Romania, and Slovakia between 2007 and 2019. Methods: A retrospective analysis of anticoagulants comprising B01AA, B01AB, B01AE, B01AF and B01AX was performed using ATC/DDD methodology. The analysis was initiated in the year before the launch of the first non-vitamin K oral anticoagulant (NOAC). The consumption of each drug was assessed based on annual data and was expressed as DDD per 1,000 population per day (DDD/TID). Results: The overall rates of anticoagulant consumption increased in all countries. Specifically, doubled in the Czech Republic, Croatia, and Slovakia, more than tripled in Hungary and more than quadrupled in Romania. Parenteral anticoagulant consumption remained stable or decreased, while the proportion of oral anticoagulants increased from an average of 61.41% in 2009 to 66.95% in 2019. The use of vitamin K antagonists declined, with the highest rate in the Czech Republic (11.16 DDD/TID in 2019). NOAC consumption showed substantial growth: from 0.002 to 8.33 DDD/TID in the Czech Republic, 0.001 to 6.73 in Croatia, 0.009 to 8.31 in Hungary, 0.0005 to 5.40 in Romania, and 0.03 to 10.77 in Slovakia. By 2019, rivaroxaban was the most commonly used NOAC in all countries, apart from Romania. Conclusion: The study showed an overall increase in the anticoagulant consumption. However, specific characteristics of individual countries need to be further analysed to better understand the different factors influencing utilization patterns. Key words: drug utilization analysis, Europe, oral anticoagulation, parenteral anticoagulation. Rostoucí spotřeba antikoagulancií v zemích střední a východní Evropy v letech 2007–2019 Úvod a cíl: S rostoucí incidencí tromboembolických onemocnění a fibrilace síní lze předpokládat rostoucí trend ve spotřebě antikoagulancií. Cílem práce bylo analyzovat spotřeby antikoagulancií v České republice (ČR), Chorvatsku, Maďarsku, Rumunsku a na Slovensku v letech 2007−2019. PharmDr. Kateřina Malá-Ládová, Ph.D. Department of Social and Clinical Pharmacy, Pharmaceutical Faculty in Hradec Králové, Charles University ladovaka@faf.cuni.cz Cit. zkr: Čes. slov. Farm. 2024;73(4):XXX-XXX Článek přijat redakcí: ??. ??. 2024 Článek přijat po recenzích: ??. ??. 2024 PLNÁ VERZE ČLÁNKU ➜ https://doi.org/10.36290/csf.2024.036 POUZE PRO PŘEDPLATITELE ČASOPISU ČESKÁ A SLOVENSKÁ FARMACIE
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