Evaluation of adherence to treatment in patients suffering from diabetes mellitus

Lucia Masaryková, Tomáš Tesař, Ľubica Lehocká, Klaudia Bernáthová

Čes. slov. farm. 2020, 69(2):67-74 | DOI: 10.36290/csf.2020.011  

Background: Diabetes mellitus type 2 (DM) is a disease which is becoming pandemic these days. A successful treatment of chronic diabetes mellitus depends on early diagnosis and proper treatment. Just as the role of the doctor in treating the disease is important, so the community pharmacist plays an important role in taking the initiative in motivating patients to adhere to individual treatment regimes. Objective: The main aim of the study was to analyze and assess patient adherence to pharmacological or non-pharmacological treatment, including the influence of the community pharmacist on that. Method: All necessary data...

The influence of «Saprogel» in the wound healing process on rats with a full-thickness wound model

Oksana Strus, Natalia Polovko

Čes. slov. farm. 2020, 69(2):75-82 | DOI: 10.36290/csf.2020.012  

The article presents the study results of the effectiveness and the mechanism of the «Saprogel» action on the wound healing process and pro-/antioxidant equilibrium in serum of rats with a full-thickness wound model. The wound healing effect of tested gel samples was evaluated by the dynamics of area change (S) and the percentage reduction of the area (PRA) of wounds on the 3^rd, 7^th, and 14^th days of the treatment. The content of lipid peroxide oxidation (LPO) products and the activity of antioxidant protection enzymes in the serum of rats were determined in the dynamics in different phases of the wound...

A cost minimization analysis of α2b-interferon supplementation in complex pharmacotherapy of rotavirus infection in newborns

Serhii O. Soloviov, Serhii H. Ubohov, Tetiana A. Aleksandrina, Olena V. Kovaliuk, Iryna V. Dziublyk, Viktor V. Trokhymchuk, Hlib V. Zahoriy

Čes. slov. farm. 2020, 69(2):83-89 | DOI: 10.36290/csf.2020.013  

Rotavirus is one of the most important causative agents of gastroenteritis in both infants and children worldwide, resulting in high mortality and morbidity, mainly in low-income, developing countries. Respective analysis of medical records of newborns hospitalized with acute gastroenteritis showed that the use of α2b-interferon in complex pharmacotherapy was characterized by faster reverse development of clinical manifestations of the disease than in patients who did not receive interferon. In our study, we also aimed to estimate the effectiveness of α2b-interferon supplementation in combination pharmacotherapy of newborns with suspected...

Formulation and technology development of vaginal pessaries with probiotic activity

Zhanna Polova, Svitlana Aleinyk, Aurelii Kazak

Čes. slov. farm. 2020, 69(2):90-99 | DOI: 10.36290/csf.2020.014  

Lactobacilli use in treatment and prevention of the vaginal microflora disorders, such as bacterial vaginosis and vulvovaginal candidiasis, is highly promising. The objective of this study was is to develop formulation and technology of the extemporal Lactobacillus casei (L. casei) ІМВ В-7280-containing medicinal product in the form of vaginal pessaries.The quality control parameters were defined in accordance with the State Pharmacopeia of Ukraine (2^nd edition) and included appearance, uniformity of texture, uniformity of mass and disintegration test. Lactobacilli assay was determined...

Advances in the use of instrumental measurement of colour in the development, production and quality control of drugs, medicinal preparations and pharmaceutical auxiliary substances III

Jan Šubert, Jozef Čižmárik, Jozef Kolář

Čes. slov. farm. 2020, 69(2):59-66 | DOI: 10.36290/csf.2020.010  

Colour is an important indicator of the quality of pharmaceuticals, medicinal products and pharmaceutical excipients. The paper summarizes advances in the use of instrumental colour measurement in synthetic medicines and medicines of non-natural origin, their dosage forms and excipients published in 2013-2019.

Nové knihy

M. Povýšilová

Čes. slov. farm. 2020, 69(2):103  

Rosuvastatin-induced rhabdomyolysis due to medication errors

Martin Vodička, Ondřej Slanař, Michal Pisár, Tomáš Šálek

Čes. slov. farm. 2020, 69(2):100-102 | DOI: 10.36290/csf.2020.015  

Case (description): A 74 years old Caucasian suffering from chronic kidney disease presented with progressive asthenia and diffuse myalgia. It was revealed that the patient used three different rosuvastatin-containing preparations in a total daily dose of 120 mg for 76 days. Laboratory investigations revealed a marked elevation of serum urea, creatinine, myoglobin, creatine kinase (CK) and transaminases. Two serious medication errors have been identified as possible major factors that synergistically contributed to the development of rosuvastatin-induced rhabdomyolysis. First, 40 mg of rosuvastatin dose was prescribed to the patient, although...