Fatty acid composition of lipids of Iris sibirica

Olga Mykhailenko, Vladimir Kovalyov, Sergey Kovalyov, Erika Toryanik, Tatyana Osolodchenko, Yurii Buidin

Čes. slov. farm. 2017, 66(5):220-226 | DOI: 10.36290/csf.2017.032  

Different Iris species are a rich source of secondary metabolites and they are widely used due to their medicinal properties, i.e. such as antibacterial, cytotoxic, hepatoprotective, antiplasmodial, and immunomodulatory effects. Determination of the fatty acid composition is necessary to create complex phytopreparations on their basis, and also, it is important for understanding of the adaptive capabilities of the plant. In our study, a comparative analysis of fatty acids composition of total lipids of the leaves and rhizomes of Iris sibirica was carried out by the gas chromatography-mass spectrometry method. The degree of unsaturated...

Development of the composition of intramammary combined preparation based on silver citrate for veterinary use

Zhanna Polova, Lyudmyla Almakayeva, Tetiana Nehoda

Čes. slov. farm. 2017, 66(5):227-232 | DOI: 10.36290/csf.2017.033  

The goal of the present study was to develop a new intramammary combination preparation for veterinary use based on silver citrate, arginine and dexpanthenol for the treatment and prophylaxis of subclinical mastitis in cattle. When creating combined medicines for veterinary use, attention must be paid to the factors that influence their stability in a combined presence, and the composition of drugs, as well as the technology for their preparation should be determined. In the current study, a qualitative and quantitative control of model mixtures of active ingredients, as well as of a silver citrate-based combined preparation was carried out. The following...

Active substances from marine organisms in clinical trials and practice

Daniel Mareček, Jana Rudá-Kučerová

Čes. slov. farm. 2017, 66(5):191-207 | DOI: 10.36290/csf.2017.030  

Oceans cover a large part of our planet and they are a home for an enormous amount of species. A lot of them are still waiting to be discovered by man, much like the chemicals they synthesize. Marine pharmacology concerns itself with the study of these chemicals and their potential use in medicine. Origin in marine species is for the most part the only thing this large and diverse group of substances have in common, so the spectrum of possible applications is quite wide. Many of these substances have a unique mechanism of action, offering new therapeutic possibilities. Although just a few of them are used in a clinical practice today (e.g. eribulin,...

Herbs for increasing breast-milk production

Zuzana Vargová, Jana Rudá-Kučerová

Čes. slov. farm. 2017, 66(5):208-219 | DOI: 10.36290/csf.2017.031  

Subjective perception of insufficient milk supply is one of the most common problems of nursing mothers. For centuries, herbs have been used to increase lactation and remain popular even today. There is only a limited number of studies proving their safety and effectivity, so their use is based primarily on previous experience. The use of certain herbs has shown that they could be effective and safe, but further research is needed to define terms of use. This paper describes preliminary findings on the mechanism of action, adverse effects and possible interactions observed in some herbs frequently used to promote lactation.

Idiopathic thrombocytopenia refractery to therapy of cyclosporine A in clinical practice - case report

Lucia Schwarzová, Zdenko Pirník, Natália Štecová

Čes. slov. farm. 2017, 66(5):233-237 | DOI: 10.36290/csf.2017.034  

Primary immune thrombocytopenia (idiopathic thrombocytopenic purpura; ITP) is an autoimmune disorder characterized by isolated thrombocytopenia without abnormalities in the erythroid and myeloid/lymphoid lineages. The incidence of ITP in adults is estimated at approximately 1.6-3.9 per 100 000 persons/year. The aim of this study was to analyze a case report of a patient with diagnosed immune thrombocytopenia (D69.3) resistant to cyclosporine A therapy as well as an evaluation of factors that could contribute to an inadequate response to cyclosporine A. The results show a multifactorial origin of thrombocytopenia and a possible effect on refractivity...

Pokroky ve farmaceutické technologii. Brno, 5. září 2017

Čes. slov. farm. 2017, 66(5):238-246  

36. technologické dni. Nové trendy v oblasti výskumu a vývoja liekov. Inovácie v oblasti zdravotníckych pomôcok. Štrbské Pleso, 25.-27. október 2017

Čes. slov. farm. 2017, 66(5):247-262  

60 rokov Katedry farmaceutickej chémie FaF UK v Bratislave

J. Čižmárik

Čes. slov. farm. 2017, 66(5):263