The quality of life of patients suffering from the osteoporosis

Lucia Masaryková, Magdaléna Fulmeková, Ľubica Lehocká, Tomáš Ďurdík

Čes. slov. farm. 2015, 64(3):72-78 | DOI: 10.36290/csf.2015.020  

Osteoporosis (OP) is a systemic skeletal disease characterized by an imbalance of bone remodelling process due to the prevalence of osteoresorption over osteosynthesis. As a result of these changes, the decrease in bone mass and density occur followed by an increase in fracture risk¹⁾. Its clinical manifestation is initially asymptomatic but in the course of time it is quite the contrary - really severe (bone pain, movement disorders, fractures) with a lot of further adverse consequences, including death²⁾. The presented study deals with the impact of osteoporosis and its consequences on the quality of life of patients. The research...

Enhancing of drug bioavailability using liquisolid system formulation

Jan Gajdziok, Barbora Vraníková

Čes. slov. farm. 2015, 64(3):55-66 | DOI: 10.36290/csf.2015.018  

One of the modern technologies of how to ensure sufficient bioavailability of drugs with limited water solubility is represented by the preparation of liquisolid systems. The functional principle of these formulations is the sorption of a drug in a liquid phase to a porous carrier (aluminometasilicates, microcrystalline cellulose, etc.). After addition of further excipients, in particular a coating material (colloidal silica), a powder is formed with the properties suitable for conversion to conventional solid unit dosage forms for oral administration (tablets, capsules). The drug is subsequently administered to the GIT already in a dissolved state,...

Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus. II. Fenugreek (Trigonella foenum-graecum)

David Koupý, Hana Kotolová, Jana Rudá Kučerová

Čes. slov. farm. 2015, 64(3):67-71 | DOI: 10.36290/csf.2015.019  

Fenugreek seeds are known for their characteristic smell of soup seasoning and as an ingredient of Indian curry. Traditionally the seeds are used as macerate for the treatment of diabetes, cough, and flatulence, to increase breast milk secretion, and for anti-inflammatory and aphrodisiac effects. The use is limited by its unpleasant smell and bitter taste which can be modified by adding mint leaves to the macerate. Antidiabetic properties are attributed mainly to galactomannan, 4-hydroxyisoleucin (4-OH-Ile), diosgenin and trigonelline. These substances demonstrate direct antidiabetic properties in clinical studies by increasing insulin secretion (4-OH-Ile),...

Pharmaceutical History of the Capuchin Monastery in Prague-Hradčany. Part I. Monastic Pharmacy

Karel Nesměrák, Jana Kunešová

Čes. slov. farm. 2015, 64(3):79-94 | DOI: 10.36290/csf.2015.021  

Based on a profound examination and thorough evaluation of archival materials and preserved equipment, the article provides a unique perspective on the unknown history of pharmacy at the capuchin monastery in Prague-Hradčany. The intramural pharmacy was established around the year 1680, and was practised to 1822. The article identifies the capuchin pharmacists and their line of succession. Pharmaceutical literature from the monastic library is listed and described, including rare manuscripts. The preserved high baroque equipment of the pharmacy is described in detail, and an iconography analysis of the hidden meaning of its unique decoration is offered.

Pharmaceutical history of capuchin monastery in Prague-Hradčan. Part II. Capuchin balsam (Balsamum capucinorum)

Karel Nesměrák, Jana Kunešová

Čes. slov. farm. 2015, 64(3):95-99 | DOI: 10.36290/csf.2015.022  

The history of traditional capuchin balsam is the focal point of the second part of the article on the unknown history of pharmacy at the capuchin monastery in Prague-Hradčany. Capuchin balsam, a medicinal speciality, was being manufactured in the monastery from the end of the 18th century till the year 1950. It is a spirit tincture, its prescription originating from the formulation by Oswald Croll. Balsamum Peruvianum, Gummiresina myrrha, Gummiresina olibanum, and Styrax are the main ingredients, besides assorted plants. The balsam was taken as an antiseptic, antiphlogistic, and analgesic. The balsam was a favoured rustic medicine, and...

Zlyhanie farmakoterapie - možnosti prevencie

Jozef Čižmárik

Čes. slov. farm. 2015, 64(3):113  

Analytická chémia

Jozef Čižmárik

Čes. slov. farm. 2015, 64(3):113  

XXXVII. pracovní dny Radiofarmaceutické sekce České společnosti nukleární medicíny ČLS JEP

Čes. slov. farm. 2015, 64(3):100-110  

Milan Lehký - deväťdesiatnikom

Jozef Čižmárik

Čes. slov. farm. 2015, 64(3):111-112