Czech and Slovak Pharmacy, 2003 (vol. 52), issue 2
Articles
Modern HPLC in the Analysis of Drugs
T. Hudecová, J. Tekeľ, E. Havránek
Čes. slov. farm. 2003, 52(2):55-67
High performance liquid chromatography found wide-spread utilization almost in all fields ofpharmaceutical analysis since the 1980s.The articlesummarizes the new knowledge and interestingfindings about HPLC used in the analysis of drugs during the last three years with a supplementof particular applications in pharmaceutical analysis.
Information System Beilstein CrossFire and Its Versatility in Medicinal Chemistry
J. Vančo
Čes. slov. farm. 2003, 52(2):68-72
The Beilstein CrossFire database system is one of the most popular, most extensive, and mostaccomplished systems presenting information about chemical substances, including drugs, andcovering the basic identification, physico-chemical, ecological, and pharmacological data. Thepresent article offers an overviewof historical evaluation of the Beilstein CrossFire database system,beginning from its founder Prof. Friedrich Conrad Beilstein till the most recent prospects about theconnection of classical data with full-text databases. The article also offers a review of the developmentof electronic information systems in the Slovak Republic, a definition...
Advances in the Development of Antituberculotics Containing No Heterocycles in thePharmacophorePart 1. Carboxylic Acid Derivatives
K. Waisser, K. Dražková
Čes. slov. farm. 2003, 52(2):73-81
The present paper is the twentieth communication in a series of review papers on the developmentof antituberculotics and the ninth communication summarizing the work in the development ofantituberculotics within recent 15 years. The first seven communications were devoted to heterocycliccompounds, the eighth to substances containing an alkylsulfanyl group in the pharmacophore.The present paper summarizes information about cyrboxylic acids, their amides, anilides, hydrazides,thioamides, thioanilides, thiohydrazides, and amidines. The communication includes paperspublished after 1980 in order to link up with a review paper devoted to the same topic published...
Pharmaceutical Importance of Alium sativum L.4. Antifungal Effect
M. Sovová, P. Sova
Čes. slov. farm. 2003, 52(2):82-87
The recent decades saw an increase in the number of systemic fungal diseases and improvementsin the identification of their causative agents. There has been an intensive search for new drugswhich would be more effective and less toxic than those already in use. From this aspect, attentionhas been paid also to garlic - its extracts and individual components, i.e., allicin, ajoen, polysulfides,essential oil. New experimental knowledge confirms a significant antifungal activity of sulfurouscompounds of garlic. The paper also mentions a possible use of employing garlic extracts or essentialoils in food industry as an alternative way of protection of foodstuffs...
Use of Penetrometry in the Evaluation of Flowability and Structure of Powdered Substances
Z. Zatloukal
Čes. slov. farm. 2003, 52(2):88-92
Usability of modified penetrometry is examined and significant relationships with routinely usedcharacteristics of flowability and structure of powdered substances are searched for in size fractionsof sodium chloride, potassium chloride, sodium citrate, and potassium citrate. A systematic study ofinterrelationships between properties made it possible to achieve sufficiently reproducible resultswithout a necessity of consolidation. By means of factor analysis, a connection between penetrometry,bulk flow rate, and Kawakita-constant was demonstrated. For multidimensional linear regresssionfor estimation of penetrometry, the significance of examined properties...
A Study of the Rheological Properties of VIVASTAR® P 5000 Hydrogels
Z. Vitková, M. Škarbalová, E. Cirbusová, J. Rak
Čes. slov. farm. 2003, 52(2):93-96
Within the framework of pre-formulation studies, the paper evaluates the rheological properties ofhydrogels whose gel-forming substance is a polymer supplied by the firm J. Rettenmaier &SöhneGMBH+CO. It is VIVASTAR® P 5000, a modified derivate of carboxymethyl starch. The evaluationof rheological properties included hydrogels with 1.5, 2.0 and 2.5 w % of VIVASTAR® P 5000.The highest viscosity was shown by the hydrogel with 2.0% concentration of the polymer. The systemwithout and with the model drug with a local anaesthetic effect was thixotropic. From the viewpointof topical administration, VIVASTAR® P 5000 in 2.0% is optimal for hydrogel...
Effect of the Saccharide Parts in the Teikoplanin Stationary Phase on the Separation ofSome Enantiomers of the Phenylcarbamic Type by the HPLC Method
T. Rojkovičová, J. Lehotay, J. Čižmárik
Čes. slov. farm. 2003, 52(2):97-101
The paper presents the results obtained with the use of two chiral stationary phases (CSP) basedon a macromolecular antibiotic agent - teikoplanin containing saccharide parts (CHIROBIOTIC T)and teikoplanin without saccharide parts (CHIROBIOTIC TAG). Racemic mixtures of 1-methyl-2--piperidinoethyl esters of 2-, 3-, and 4-alkoxyphenylcarbamic acids were examined. The investigationincluded interactions between separated substances and CSP, and the effect of separation of theenantiomers under study on the value of the differentiation factor (Rij) under identical chromatographicconditions with the use of the method of high-performance liquid chromatography...