JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2020, 69(3):107-111 | DOI: 10.36290/csf.2020.017

Ingavirin might be a promising agent to combat Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2)

Ivan Malík1,2,*, Gustáv Kováč2, Tereza Padrtová3, Lucia Hudecová2
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic
2 Institute of Chemistry, Clinical Biochemistry and Laboratory, Medicine, Faculty of Medicine, Slovak Medical University in Bratislava, Slovak Republic
3 Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic

The Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-19 (COVID-19) pandemic, caused by the virus, have changed the world in just half a year. Lack of effective treatment, coupled with etiology of COVID-19, has resulted in more than 500,000 confirmed deaths at the time of writing, and the global economy is at an unseen unprecedented low level with unknown near- and long-term consequences. Ingavirin has been considered a non-toxic broad-spectrum antiviral with a complex mechanism of action. The molecule was originally designed for the prophylaxis and treatment of flu caused by both Influenza A and B viruses and for the treatment of viral causes of acute respiratory illness. The article hypothesized that the efficiency of given 1H-imidazol-4-yl heterocyclic scaffold-containing compound against SARS-CoV-2 might be connected with its ability to interfere with specific heterogeneous nuclear ribonucleoproteins (A1, for example). These specific cellular RNA-binding proteins showed affinity to Severe Acute Respiratory Coronavirus (SARS-CoV) nucleocapsid (N) protein, which shared high homology with the N protein of SARS-CoV-2 and the fact was expressed by a sequence identity of 90.52%. Impairing of the interactions between nuclear ribonucleoproteins and nucleocapsid (N) protein of SARS-CoV-2 might result in the inhibition of a viral replication cycle. Additional immunomodulating properties of ingavirin could be favorable for induction of adaptive immunity of host cells.

Keywords: SARS-CoV-2; COVID-19; ingavirin; heterogeneous nuclear ribonucleoproteins; nucleocapsid (N) protein

Received: June 29, 2020; Accepted: July 1, 2020; Published: March 1, 2020  Show citation

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Malík I, Kováč G, Padrtová T, Hudecová L. Ingavirin might be a promising agent to combat Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2). Čes. slov. farm. 2020;69(3):107-111. doi: 10.36290/csf.2020.017.
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