JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2020, 69(2):75-82 | DOI: 10.36290/csf.2020.012

The influence of «Saprogel» in the wound healing process on rats with a full-thickness wound model

Oksana Strus1,*, Natalia Polovko2
1 Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
2 Department of Drug Technology, National University of Pharmacy, Kharkiv, Ukraine

The article presents the study results of the effectiveness and the mechanism of the «Saprogel» action on the wound healing process and pro-/antioxidant equilibrium in serum of rats with a full-thickness wound model. The wound healing effect of tested gel samples was evaluated by the dynamics of area change (S) and the percentage reduction of the area (PRA) of wounds on the 3rd, 7th, and 14th days of the treatment. The content of lipid peroxide oxidation (LPO) products and the activity of antioxidant protection enzymes in the serum of rats were determined in the dynamics in different phases of the wound healing process in rats. «Saprogel» treatment of full-thickness wounds in rats reduced their healing time by 24.5% (p < 0.05), but there was no statistically significant difference between the effect of «Saprogel» and the comparator product on the duration of wound healing. The content of LPO products in the rat serum when using «Saprogel» was reduced and the enzymes activity of the antioxidant protection SOD and CAT was normalized, indicating that one of the mechanisms of wound healing action of «Saprogel» is its antioxidant properties.

Keywords: sapropel extract; dermatotropic gel product; wound healing process; pro-, antioxidant equilibrium

Received: December 19, 2019; Accepted: March 19, 2020; Published: February 1, 2020  Show citation

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Strus O, Polovko N. The influence of «Saprogel» in the wound healing process on rats with a full-thickness wound model. Čes. slov. farm. 2020;69(2):75-82. doi: 10.36290/csf.2020.012.
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