JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2019, 68(3):119-124 | DOI: 10.36290/csf.2019.013

Selection of technological parameters for the preparation of the combined oral solution Maglycimet™

Daria V. Snehyrova, Liudmila G. Almakaieva*, Olexandra S. Kran
National University of Pharmacy, Kharkiv, Ukraine

The problem of magnesium deficiency is an urgent issue of modern humanity. The population of many countries has a tendency to reduce the intake of this element in the daily diet. Its level decreases due to stress, inappropriate lifestyle, increased excretion from the body because of influence of medicines, etc. Therefore, creation of magnesium-containing medicines is a perspective scientific area. Currently at the pharmaceutical market, combination drugs with a multi-therapeutic effect are preferred. We have developed a technology for the preparation of the combined oral solution named Maglycimet™, which consists of the following active pharmaceutical ingredients: magnesium aspartate, magnesium glutamate, glycine, methylcobalamin. Technological parameters of the solution preparation were established. Temperature modes and the loading order of main and auxiliary substances were studied and determined. The valuable point of the preparation of this medicine was to obtain the salts magnesium aspartate and magnesium glutamate directly in the reaction mixture. Based on the theoretical and experimental studies, technological parameters for the preparation of these salts were chosen. In this experimental study, the main indicators of the quality of the solution at the preparation stage were evaluated: organoleptic properties, pH, density, quantitative content of magnesium, glycine, methylcobalamin. The results indicated the significance of further research for subsequent industrial production of the developed medicine by Ukrainian manufacturers.

Keywords: magnesium deficiency; magnesium salts; technology; oral solution

Received: April 21, 2019; Accepted: May 30, 2019; Published: March 1, 2019  Show citation

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Snehyrova DV, Almakaieva LG, Kran OS. Selection of technological parameters for the preparation of the combined oral solution Maglycimet™. Čes. slov. farm. 2019;68(3):119-124. doi: 10.36290/csf.2019.013.
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