JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2018, 67(3):95-100 | DOI: 10.36290/csf.2018.013

Inflammatory bowel disease: factors involved in pathogenesis

Boris Dudík, Hana Kiňová Sepová*, Andrea Bilková
Katedra bunkovej a molekulárnej biológie liečiv, Farmaceutická fakulta Univerzita Komenského v Bratislave, SR

The incidence of inflammatory bowel disease (IBD) in developed countries increases every year. The aetiology is still not completely understood and its clarification is a key prerequisite for effective prophylaxis and therapy. IBD is most-likely caused by a combination of several factors: environmental, genetic, immunological, and disruption of intestinal microbiota composition - dysbiosis. "Westernization" of lifestyle and urbanization seem to be among the most serious environmental factors. The pathogenesis is also influenced by the imbalance between the TH1 and TH2 cellular response and the expression of genes involved in T cell response and immunodeficiency. Last but not least, the worldwide overuse of antimicrobial drugs depletes the microbiome, which has a direct impact on the development of the dysbiosis. The subject of this review is a detailed characterization of the above-mentioned factors involved in the onset and development of IBD.

Keywords: gut microbiota; inflammatory bowel disease; immunopathogenesis; dysbiosis

Received: June 7, 2018; Accepted: June 19, 2018; Published: March 1, 2018  Show citation

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Dudík B, Kiňová Sepová H, Bilková A. Inflammatory bowel disease: factors involved in pathogenesis. Čes. slov. farm. 2018;67(3):95-100. doi: 10.36290/csf.2018.013.
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