JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2017, 66(5):227-232 | DOI: 10.36290/csf.2017.033

Development of the composition of intramammary combined preparation based on silver citrate for veterinary use

Zhanna Polova1,*, Lyudmyla Almakayeva2, Tetiana Nehoda1
1 O. O. Bogomolets National Medical University, Department of Pharmaceutical and Industrial Technology of Medicines, Kiev, Ukraine
2 National University of Pharmacy Kharkiv, Ukraine, Head, Laboratory of Parenteral and Oral Liquid Medicines

The goal of the present study was to develop a new intramammary combination preparation for veterinary use based on silver citrate, arginine and dexpanthenol for the treatment and prophylaxis of subclinical mastitis in cattle. When creating combined medicines for veterinary use, attention must be paid to the factors that influence their stability in a combined presence, and the composition of drugs, as well as the technology for their preparation should be determined. In the current study, a qualitative and quantitative control of model mixtures of active ingredients, as well as of a silver citrate-based combined preparation was carried out. The following parameters that define intramammary drug stability were studied: clarity, pH, and the quantitative content of the active ingredient. Based on the experimental studies, optimal pH limits for a new preparation were determined ranging from 6.4 to 6.7. Considering the instability of solutions based on silver citrate, studies on the stabilization of the preparation were conducted at the obtained pH values. As the result, we used povidone, which possessed the stabilizing properties. The amount of arginine that provides the optimum pH level for the selected combination of active ingredients was also determined. In conclusion, the optimal composition of an intramammary preparation for veterinary medicine in 10 ml ampoules with a shelf life of 6 months was developed.

Keywords: silver citrate; arginine; dexpanthenol; intramammary dosage form; stability

Received: July 27, 2017; Accepted: October 18, 2017; Published: May 1, 2017  Show citation

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Polova Z, Almakayeva L, Nehoda T. Development of the composition of intramammary combined preparation based on silver citrate for veterinary use. Čes. slov. farm. 2017;66(5):227-232. doi: 10.36290/csf.2017.033.
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