JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2012, 61(6):282-284

Phenyl salicylates - a new group of potential antituberculotics

Karel Waisser1,*, Eva Novotná2, Jiří Kuneš1, Jiřina Solaříková3
1 Charles University in Prague, Faculty of Pharmacy in Hradec Králové
2 Department of Biochemical Sciences
3 Regional Institute of Public Health, Ostrava

Antimycobacterial activity of phenyl salicylates (salols) was studied in connection with antituberculotic activity of salicylic derivatives. Phenyl salicylates are esters. Our attention was previously oriented on amides. Phenyl salicylates (salols) represent a new group of antimycobacterial compounds. They are less active than the corresponding amides. The most active compound in the group under study is substituted on phenyl in the salicyl moiety with a 4-methoxy group. The study reports a new item of information about antimycobacterial salicylic derivatives.

Keywords: salols; mycobacterium; antimycobacterial activity; phenyl salicylate

Received: October 10, 2012; Accepted: November 13, 2012; Published: June 1, 2012  Show citation

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Waisser K, Novotná E, Kuneš J, Solaříková J. Phenyl salicylates - a new group of potential antituberculotics. Čes. slov. farm. 2012;61(6):282-284.
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    References

    1. WHO (2010) Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response, 2010. [cit. 2010-10-14]. Available from: http://whqlibdoc.who.int/publications/2010/9789241599191_eng.pd.
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