Čes. slov. farm. 2011, 60(1):11-16
Energy evaluation of the compaction process of directly compressible isomalt
- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Czech Republic
The paper compares the compressibility of two directly compressible isomalts, galenIQ™ 720 and galenIQ™ 721, using the energy evaluation of the compaction process by means of the force--displacement profiles. It evaluates the energies for friction, energies accumulated by the tablet, energy of decompression, energy of compaction and plasticity in pure dry binders, in dry binders with lubricants (0.5 and 1% of magnesium stearate and sodium stearyl fumarate) and further in the tableting materials containing the model ingredients acetylsalicylic acid and ascorbic acid. The results of the study have revealed that lower values of the energy for friction and compaction with the identical compression force are found by the substance galenIQ 720, which is therefore better compressible than the substance galenIQ 721.
Keywords: directly compressible isomalt; force-displacement profile; lubricants
Grants and funding:
The study was supported by the grant MSM 0021620822 and by the firm PALATINIT GmbH Germany, which supplied the samples of the dry binders tested.
Received: January 5, 2011; Accepted: January 15, 2011; Published: January 1, 2011 Show citation
References
- Ragnarsson, G.: Force-diplacement and network measurements. In Alderborn, G., Nyström, Ch., eds. Pharmaceutical powder compaction technology, Inc. New-York: Marcel Dekker 1996; 177-197.
- Komárek, P., Rabišková, M.: Technologie léků. 3. vyd. Galén: Praha 2006; 228-240.
- Mužíková, J., Pavlasová, V.: A study of the properties of tablets from directly compressible isomalt. Čes. slov. Farm. 2009; 58, 172-178.
- Bolhuis, G. K., Armstrong, N. A.: Excipients for direct compaction - an update. Pharm. Dev. Tech. 2006; 11, 111-124.
Go to original source... 
Go to PubMed... - PALATINIT GmbH: galenIQ™ - The smart excipient. Fir. Lit., 2007, http//www.beneo-paltinit.com (1. 11. 2007).
- Bolhuis, G. K., Chowhan, Z. T.: Materials for direct compaction. In Alderborn, G., Nystrőm, Ch. (eds.). Pharmaceutical Powder Compaction Technology, Inc. New York: Marcel Dekker 1996; 419-500. Go to original source...