Čes. slov. farm. 2010, 59(2):59-66
A study of the compaction process and the properties of tablets from two types of directly compressible sorbitol
- Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Czech Republic
The paper deals with the study of energy conditions in the course of compaction and the properties of tablets from two types of the directly compressible sorbitol Sorbitab™ SD 250 and Sorbitab™ SD 500. The tested properties included tensile strength of tablets and disintegration time of tablets, examined in dependence on compression force, addition of two types of lubricants in two concentrations, and two types of active ingredients in one concentration. A comparison of both types of directly compressible sorbitol revealed that the negative moment in the use of Sorbitab SD 500 is the effect of the presence of lubricants on the strength of the compacts, and furthermore a more significant prolongation of disintegration time of tablets by the action of lubricants in contrast to Sorbitab SD 250. The energy balance of compression showed a higher value of total energy of compression for Sorbitab SD 500 due to higher values of energy required for friction and the energy accumulated by the tablet.
Keywords: directly compressible sorbitol; lubricants; tensile strength of tablets; disintegration time; force-displacement profile
Grants and funding:
The study was supported by the grant MSM 0021620822 and by the firm SPI Pharma, which supplied the samples of the dry binders tested.
Received: February 16, 2009; Accepted: March 15, 2010; Published: February 1, 2010 Show citation
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