Studies of the properties of tablets from directly compressible isomalt

The paper deals with the study of the properties of tablets from two types of directly compressible isomalt - namely galenIQ^TM 720 and galenIQ^TM 721. The study focuses on the dependence of tensile strength and disintegration time of the tablets, on both the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv) with the concentrations of 0.5% and 1%, and a 50% addition of model active ingredients, namely ascorbic acid and acetylsalicylic acid. The used compression forces were 6, 8 and 10 kN, tablets containing drugs were compressed only with the force of 10 kN. The tensile strength of tablets from both substances increased with increasing compression force, the presence of lubricants did not result in any decrease in strength. The disintegration time of tablets was longer with the use of substance galenIQ^TM 720, it was prolonged by lubricants and increased with increasing compression force for both substances. The presence of drugs decreased tensile strength, and the tablets containing acetylsalicylic acid showed higher tensile strength. For both drugs, differences within the type of isomalt or lubricants were not significant. The disintegration time of tablets was shorter when ascorbic acid was used; it was the shortest in the case of galenIQ^TM 721 with Pruv, but in the case of acetylsalicylic acid the disintegration time was the shortest with galenIQ^TM 721 with magnesium stearate.

Keywords: directly compressible isomalt; lubricants; tensile strength of tablets; disintegration time of tablets

Grants and funding:

The study was supported by the grant MSM 0021620822 and by the firm PALATINIT GmbH Germany, which supplied the samples of the dry binders tested.